Vesicular Skin Diseases

Autoimmune Skin Disorders Vesiculopustular diseases

Disease

Pemphigus foliaceus

Pemphigus erythematosus

Superficial pustular drug reactions

Mucous membrane pemphigoid

Bullous pemphigoid

Vesicle location

subcorneal

superficial

superficial

subepidermal

subepidermal

Inflammatory cell

neutrophils, eosinophils

gross features

dorsal muzzle, nasal planum, pinnae, periorbital skin, pawpads

red blood cells, eosinophils, neutrophisl, empty face only, depigmentation

head pinnae, or generalized

pathogenesis

Desmogelin 1 antibodies

antibasement membrane circulating antibodies

acantholysis

yes

if prominent the drug related pemphigus is preferred

interface dermatitis interstitial mixed, with basal cell neuts and eos, or damage, dermal inflammation lichenoid in facial lymphocytes, predominant forms histiocytes, plasma cells

superficial perivascular to interstitial mixed inflammation with neutrophils predominating. Eosinophils may be prominent

Vesiculopustular diseases

Disease

Pemphigus vulgaris

Paraneoplastic pemphigus

epidermolysis bullosa (hereditary or acquired)

Vesicle location

suprabasilar

suprabasilar, intraepidermal, apoptosis

subepidermal

Inflammatory cell

neutrophils and acantholytic cells

gross features

oral cavity and mucocutaneous junctions, pinnae, nasal planum, oral cavity, lip margins, genitalia, anus

pathogenesis

desmoglein 3

neutrophils, eosinophils

mucosa and mucocutaneous junctions

junctional and dystrophic forms

basal cell layer problem

acantholysis secondary ulceration and fibrinosuppurative inflammation; dermal inflammation variable lymphocytes plasma cells, neutrophils Interface dermatitis

superficial and periadnexal dermis lymphocytes, plasma cells

autoantibodies against the bullous pemphigoid antigen in basal keratinocytes

mild inflammation, eosinophils, superficial neutrophils, neutrophils, and eosinophils, lymphocytes, mixed and plasma cells. Lichenoid mononuclear cells superfically and perivascularly

Ischemic Dermatopathy/ Canine dermatomyositis

specific features

Discoid Lupus Erythematosus

Systemic Lupus Erythematosus

Scattered basal cell apoptosis, degeneration of basal cell variable, basal cell individual basal degeneration vacuolation, apoptosis cells, can look (apoptotic and of basal cells. Dermalapoptotic, can show vacuolar), disrupts epidermal separation subepidermal dermal epidermal vesicles junction

Inflammatory cell

lymphocytes

gross features

face

face, planum nasale; depigmentation, erythema, scaling,

pathogenesis

multiple vasculopathic syndromes

photo-aggravated

diffuse mild, interface dermatitis, lymphocytes, lymphocytes, dermal inflammation histiocytes, mast macrophages, cells, plasma cells, plasma cells fewer neutrophils neutrophils Other Pustular diseases Impetigo Superficial pyoderma Candidiasis Dernmatophytosis Sterile pustular erythroderma of miniature shanauzers

erythema multiforme

apoptosis, vacuolation of the BM zone

lymphocytes pleomorphic

interface dermatitis extending to superficial hair follicles, lymphocytes and macrophages, with some neutrophilas and plasma cells