The Effect Of Ascorbic Acid Deficiency On Leukocyte Phagocytosis And Killing Of Actinomyces Viscosus.
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The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces viscosus.
Author: Goldschmidt, M C : Masin, W J : Brown, L R : Wyde, P R Citation: Int-J-Vitam-Nutr-Res. 1988; 58(3): 326-34 The ascorbic acid content of guinea pig leukocytes is reduced by a factor of 16:1 between normal and scorbutic guinea pigs. Ascorbic acid deficiencies do not appear to affect phagocytic activity but do change leukocyte morphology. A deficiency of this vitamin appears to significantly interfere with the in vitro bactericidal effectiveness of circulating leukocytes against ingested, cell-associated, and extracellular bacterial cells of the oral pathogen, Actinomyces viscosus. Leukocytes from scorbutic guinea pigs killed 13% of ingested and cell-associated Actinomyces viscosus compared to 83% killed by normal leukocytes by both acridine orange staining and Abstract: viable count. Degranulation resulted in extracellular killing in normal but not scorbutic leukocytes. This decreased bactericidal activity can be reversed by adding supplements of the vitamin to the diet of scorbutic animals. Chemotactic responses were much lower in vivo and absent in vitro in scorbutic leukocytes. The acridine orange staining technique is an excellent indicator of leukocyte health. This study supports the important role for ascorbic acid in leukocyte function and also discusses its probable protective and bactericidal activities related to oral pathogens. Review None References: Copyright Hogrefe : & : Huber Publishers. Abstracts are reprinted by the permission of the publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic jo : Notes: urnal sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home page. Language: English Publication Journal-Article Type: Keywords:
Actinomyces pathogenicity : Ascorbic Acid physiology : Ascorbic Acid Deficiency blood : Blood Bactericidal Activity : Leukocytes physiology : Phagocytosis
URL: http://verlag.hanshuber.com/Zeitschriften/IJVNR/index.html
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About IBIDS
Record Detail
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Journal Info
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ODS Home
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Return to previous page
Save: Title:
The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces viscosus.
Author: Goldschmidt, M C : Masin, W J : Brown, L R : Wyde, P R Citation: Int-J-Vitam-Nutr-Res. 1988; 58(3): 326-34 The ascorbic acid content of guinea pig leukocytes is reduced by a factor of 16:1 between normal and scorbutic guinea pigs. Ascorbic acid deficiencies do not appear to affect phagocytic activity but do change leukocyte morphology. A deficiency of this vitamin appears to significantly interfere with the in vitro bactericidal effectiveness of circulating leukocytes against ingested, cell-associated, and extracellular bacterial cells of the oral pathogen, Actinomyces viscosus. Leukocytes from scorbutic guinea pigs killed 13% of ingested and cell-associated Actinomyces viscosus compared to 83% killed by normal leukocytes by both acridine orange staining and Abstract: viable count. Degranulation resulted in extracellular killing in normal but not scorbutic leukocytes. This decreased bactericidal activity can be reversed by adding supplements of the vitamin to the diet of scorbutic animals. Chemotactic responses were much lower in vivo and absent in vitro in scorbutic leukocytes. The acridine orange staining technique is an excellent indicator of leukocyte health. This study supports the important role for ascorbic acid in leukocyte function and also discusses its probable protective and bactericidal activities related to oral pathogens. Review None References: Copyright Hogrefe : & : Huber Publishers. Abstracts are reprinted by the permission of the publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic jo : Notes: urnal sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home page. Language: English Publication Journal-Article Type: Keywords:
Actinomyces pathogenicity : Ascorbic Acid physiology : Ascorbic Acid Deficiency blood : Blood Bactericidal Activity : Leukocytes physiology : Phagocytosis
URL: http://verlag.hanshuber.com/Zeitschriften/IJVNR/index.html
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