Stem Cell Treatment For Cerebral Palsy- Results

Autologous Stem Cell Transplantation in patients with Cerebral Palsy (n=30) Introduction Cerebral Palsy is a non-progressive disorder caused by damage to the motor control centers of the develo1 1, 2 ping brain . The incidence of Cerebral Palsy varies between 2.12 to 2.45 per 1000 live births . In more than 3 75%, the brain damage happened during pregnancy. At the moment there is no cure for Cerebral Palsy . Treatment with Autologous Stem Cells seems to be a promising therapy to improve the condition of the Ce4 rebral Palsy patient .

Methods 30 patients with Cerebral Palsy were treated with Autologous stem cells by the XCell-Center. Injection of the Stem Cells was performed by Lumbar Puncture. 200 ml of Bone Marrow was extracted out of the Iliaca crest and was concentrated for transplantation using gradient centrifugation (mean number of given cells was 6.000.000). After treatment the patients were evaluated using a post treatment survey. The results of 30 treated patients are presented in this poster.

Results

CP - Results of Stem Cell Treatment (N=30)

The mean age of the treated patients was

100%

9.8 years and the age of 50% of the treated patients was below 6.5 years. The 21

oldest patient was 44 years old. Gender

50%

+

distribution was nearly equal. Nearly 70%

9

of the treated patients mentioned improvements (first figure).

No Change

Improvement

The type of improvements included a de-

Upper extremities (n=21/N=30)

40% 30% 20%

No

10%

Yes

28,6 %

ha nd /fi ng er s

71,4 %

M ot or

cu p Ho ld

Fin e

A major decrease or even absence of epileptic seizures was reported in nearly 20%

61,9 %

sk ills ha nd /fi ng er s

66,7 %

w ith ou ts pi llin g

57,1 %

0%

co or di na tio n

observed in 40% of the responders.

50%

Be tte r

tion and the ability to speak better was

60%

ha nd /fi ng er s

were reported. Improvement of articula-

70%

us e

alone and even walking without help

80%

Be tte r

communication. Sitting alone, standing

90%

ar m /h an d

mental functions resulting in improved

100%

Le ss Sp as tic ity

in posture stability and an improvement in

Cerebral Palsy

Type of improvements CP

crease of spasticity, a better coordination, an increase in motor function, an increase

0%

Type of improvements CP

of the responders.

Lower extremities (n=21/N=30)

100%

40% 30% 20%

No

10%

Yes

In summary, Autologous Stem Cells injec-

19,0 %

Be tte r

w al kin g

33,1 %

sta nd in g

62,4 %

le gs /fe et

le gs /fe et Le ss Sp as tic ity

Conclusions

42,9 %

Be tte r

42,9 %

0%

co or di na tio n

the number of transplanted stem cells.

50%

Be tte r

correlation between the outcome and

60%

le gs /fe et

Stem Cells. The results show no apparent

70%

us e

weeks after the application of autologous

80%

Be tte r

All the improvements started within 8

90%

ted in the spinal cavity has shown to have a strong positive effect on the health

CP – Results of Stem Cell Treatment

status of nearly 70% of the treated pa-

Duration in weeks before first effects got noticed (n=21/N=30)

tients. Stem cell transplantation seems to

Table 3: Duration in weeks for first Improvements (n=30)

be a safe and potentially powerful therapy for this group of patients. Scientific proof will be obtained by a planned double blind randomized control clinical trial.

References

Counts

Percentage

After first week

6

28,60 %

After second week

3

14,26 %

After third week

3

14,26 %

After fourth week

3

14,26 %

After eight weeks

6

28,60 %

Total

21

100%

1. Pharoah PO. Epidemiology of cerebral palsy: a review. Journal of the Royal Society of Medicine. Jul 1981;74(7):516-520. 2. Westbom L, Hagglund G, Nordmark E. Cerebral palsy in a total population of 4-11 year olds in southern Sweden. Prevalence and distribution according to different CP classification systems. BMC pediatrics. 2007;7:41. 3. O'Shea TM. Diagnosis, treatment, and prevention of cerebral palsy. Clinical obstetrics and gynecology. Dec 2008;51(4):816-828. 4. Goldman SA, Schanz S, Windrem MS. Stem cell-based strategies for treating pediatric disorders of myelin. Human molecular genetics. Apr 15 2008;17(R1):R76-83.