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Clarivate Analytics Web of Science 1.0 J Ladio, AH Acosta, M AF Ladio, Ana H. Acosta, Marina TI Urban medicinal plant use: Do migrant and non-migrant populations have similar hybridisation processes? SO JOURNAL OF ETHNOPHARMACOLOGY LA English DT Review DE Urban society; Urban ethnobotany; Innovations; Fusion, change ID AIRES-LA PLATA; BUENOS-AIRES; HERBAL MEDICINES; EL-ALTO; ETHNOPHARMACOLOGICAL FIELD; DIETARY-SUPPLEMENTS; KNOWLEDGE; MARKETS; ETHNOBOTANY; PRODUCTS AB Ethnopharmacological relevance: Urban migrant herbal medicine is an important topic on a global scale. Through bibliographical analysis of published studies we can get an overview of the different hybridisation processes at work in cities around the world, the main medicinal plants used and the principal ailments treated. We analysed the differential characteristics of urban ethnobotanical studies involving transnational migrant and non-migrant populations, in order to contribute useful information for the design of public health policies. Materials and methods: A systematic and integrative revision was conducted, leading to a final selection of 66 primary sources, including studies with and without immigrants. In both cases, richness (S), considered as the sum of all species cited in the work, botanical families and reported ailments were recorded. Based on the work of Ladio and Albuquerque (2014) the main hybridisation processes identifiable in the literature were assessed. These were: fusion, relocation, recombination of different species, their restructuring as medicinal targets, spatial segregation in usage, innovations found in the circulation and consumption of the plants, and the presence of simultaneous coexistence of different symbolic universes in plant medical practices. Data Analysis: This was qualitative and quantitative, including both in-depth interpretative content analysis of the studies and frequency analysis of numerical data, such as species richness, botanical families, ailments and the hybridisation processes detected. A multinomial logistic regression model was used to analyse whether the probability of medicinal plant hybridisation processes occurring was the same in literature with and without migrants. Results: A total of 522 medicinal species formed part of the main urban ethnobotany worldwide; the majority were cosmopolitan in distribution and belonged to the Asteriaceae and Lamiaceae families. Only 21% of these species appeared in both migrant and non-migrant studies. Most were used for gastrointestinal and hepatic ailments. Surprisingly, culture-related illnesses were not frequently mentioned, probably due to lack of recognition and re-interpretation by authors. Logistic analysis showed that in the studies with migrants, relocation and restructuring of plant use were the most frequently identified processes, while in the studies involving only non-migrants fusion was 4 times more likely to be found than in studies with migrants. Conclusions: Our research on hybridisation processes shows that cities constitute an environment that fosters a rapid exchange of practices and knowledge about the available species. Studies with migrants have shown that they reproduce traditional models in their use of plants, and so relocation and restructuring of their herbal medicine are the principal processes. Health risks in this case are related to the difficulties faced by these groups in obtaining their plants and reproducing their practices. In the case of fusion processes observed in nonmigrants, who do not normally have a long history or much experience of plant use, errors or poisoning may result from misuse. This information highlights the importance of considering these processes in health policies, particularly when

there are no significant quality controls of these resources. C1 [Ladio, Ana H.] Univ Nacl Comahue, CONICET, INIBIOMA, Grp Etnobiol, Quintral 1250, San Carlos De Bariloche, Rio Negro, Argentina. [Acosta, Marina] UNJu, CONICET, INECOA, Lab Bot Sistemat & Etnobot LABOSyE, San Salvador De Jujuy, Argentina. RP Ladio, AH (reprint author), Univ Nacl Comahue, CONICET, INIBIOMA, Grp Etnobiol, Quintral 1250, San Carlos De Bariloche, Rio Negro, Argentina. EM [email protected] FU Consejo Nacional de Investigations Cientfficas y Tecnicas (CONICET) of Argentina; Universidad Nacional de Jujuy FX We are deeply grateful to Dra. Nilda Dora Vignale for her willingness to help, and for sharing her knowledge and experience. We also thank the four reviewers for their suggestions that greatly enriched this manuscript. This investigation was supported by the Consejo Nacional de Investigations Cientfficas y Tecnicas (CONICET) of Argentina, and the Universidad Nacional de Jujuy. CR Abarzua FD, 2014, BOL GEOGR, V35, P45 Acosta M. E., 2013, THESIS Acosta ME, 2017, B LATINOAM CARIBE PL, V16, P34 Acosta ME, 2015, GAIA SCI, V9, P90 Agresti A., 1996, INTRO CATEGORICAL DA Hurrell JA, 2014, ETHNOBIOL CONSERV, V3, DOI 10.15451/ec2014-6-3.3-1-11 Hurrell JA, 2013, B LATINOAM CARIBE PL, V12, P499 Hurrell JA, 2011, B LATINOAM CARIBE PL, V10, P443 Albuquerque U. P., 2008, METODOS TECNICAS PES, P145 Aldama N. J., 2015, CIENTIFICA TECNOLOGI, V12, P331 AMAT A G, 1991, Acta Farmaceutica Bonaerense, V10, P153 Antih J., 2016, Revista de Fitoterapia, V16, P141 Arenas P. M., 2010, EDICIONES TRANSFORMA, P297 Arenas P.M., 2011, BONPLANDIA, V20, P251 Arenas Patricia M., 2007, Kurtziana, V33, P193 Bach HG, 2014, REV BRAS FARMACOGN, V24, P258, DOI 10.1016/j.bjp.2014.04.001 Balick MJ, 2000, ECON BOT, V54, P344, DOI 10.1007/BF02864786 Barboza Gloria E., 2009, Kurtziana, V34, P7 Basualdo I., 2014, Dominguezia, V30, P47 Bennett BC, 2008, J ETHNOPHARMACOL, V116, P422, DOI 10.1016/j.jep.2007.12.006 Bhamra SK, 2017, PHYTOTHER RES, V31, P1786, DOI 10.1002/ptr.5911 de Almeida CDCBR, 2012, EVID-BASED COMPL ALT, DOI 10.1155/2012/679373 Bussmann RW, 2006, J ETHNOBIOL ETHNOMED, V2, DOI 10.1186/1746-4269-2-47 Bussmann RW, 2016, J ETHNOPHARMACOL, V193, P76, DOI 10.1016/j.jep.2016.07.074 Bussmann RW, 2007, NO PERU J ETHNOBIOL, V3, P1, DOI DOI 10.1186/1746-4269-3-37 Cambi Viviana N., 2001, Acta Farmaceutica Bonaerense, V20, P33 Castaneda R, 2017, B LATINOAM CARIBE PL, V16, P136 Ceuterick M, 2008, J ETHNOPHARMACOL, V120, P342, DOI 10.1016/j.jep.2008.09.004 Ceuterick M, 2017, SOC SCI MED, V177, P43, DOI 10.1016/j.socscimed.2017.01.026 Ceuterick M, 2011, J ETHNOPHARMACOL, V136, P27, DOI 10.1016/j.jep.2011.03.038 Chan Y. H., 2005, SMJ Singapore Medical Journal, V46, P259 Cuassolo F., 2009, THESIS Cuassolo F, 2010, B LATINOAM CARIBE PL, V9, P165 de Albuquerque UP, 2007, J ETHNOPHARMACOL, V110, P76, DOI 10.1016/j.jep.2006.09.010 de Medeiros PM, 2013, J ETHNOPHARMACOL, V150, P729, DOI 10.1016/j.jep.2013.09.026 Abreu DBD, 2015, J ETHNOPHARMACOL, V175, P124, DOI 10.1016/j.jep.2015.09.019 Degen de Arnia R., 2014, B LATINOAM CARIBE PL, V13, P213 Souza RKD, 2014, J ETHNOPHARMACOL, V157, P99, DOI 10.1016/j.jep.2014.09.001 Domenach H., 2007, MOVILIDAD PROCESOS M, V274 ETKIN NL, 1982, SOC SCI MED, V16, P1559, DOI 10.1016/0277-9536(82)90167-8 Fonseca FN, 2018, ECON BOT, V72, P56, DOI 10.1007/s12231-018-9405-7

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Li, XB AF Sun, Chongzhi Wu, Yang Jiang, Bei Peng, Ying Wang, Mengyue Li, Jiaxun Li, Xiaobo TI Chemical components from Metapanax delavayi leaves and their anti-BHP activities in vitro SO PHYTOCHEMISTRY LA English DT Article DE Metapanax delavayi; Araliaceae; Anti-BPH activity; Oleanane-type triterpene saponin; Eudesmane glycoside ID TRITERPENOID SAPONINS; BARK; SEED AB Two previously undescribed oleanane-type triterpene saponins named liangwanosides III-IV and one on described eudesmane glycoside named liangwanoside A were obtained from the leaves of Metapanax delavayi, a Chinese folk medicine especially for tea used in Yunnan, together with four known compounds. The structures of the undescribed compounds were determined by detailed spectroscopic (1D/2D NMR), HR-ESI-MS data analysis and chemical evidence. The activity against human benign prostate hyperplasia was evaluated with BPH-1 cell line. Most of the isolated compounds showed moderate inhibitory activity against BPH-1 cells at 100 and 50 mu M in vitro. C1 [Sun, Chongzhi; Wu, Yang; Peng, Ying; Wang, Mengyue; Li, Xiaobo] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China. [Jiang, Bei] Dali Univ, Inst Mat Med, Coll Pharm & Chem, Dali 671000, Peoples R China. [Li, Jiaxun] Lanping Cty Bur Agr, Lanping 671400, Peoples R China. RP Li, XB (reprint author), Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China. EM [email protected] CR Bukhari S., 2015, J SERB CHEM SOC, V81, P55 Committee F. O. C. E, 2007, FLORA CHINA, V13 Ge F., 2000, CHIN WILD PLANT RESO, V19, P50 GORIN PAJ, 1975, CAN J CHEM, V53, P1212, DOI 10.1139/v75-168 Hao XC, 2015, BIOCHEM SYST ECOL, V61, P156, DOI 10.1016/j.bse.2015.06.012 KASAI R, 1987, CHEM PHARM BULL, V35, P1486 Kim KH, 2011, PLANTA MED, V77, P1555, DOI 10.1055/s-0030-1270781 Li X., 2015, BEIJING AGR, V17, P89 Liang D, 2011, J NAT PROD, V74, P2128, DOI 10.1021/np2004038 Liu Z., 2015, J DALI U, V4, P1 Mair CE, 2018, J NAT PROD, V81, P515, DOI 10.1021/acs.jnatprod.7b00774 Mao YW, 2014, J AGR FOOD CHEM, V62, P5581, DOI 10.1021/jf5012177 Matsunami K, 2010, CHEM PHARM BULL, V58, P438, DOI 10.1248/cpb.58.438 Miu M., 2005, THESIS Setzer WN, 2008, CHEM NAT COMPD+, V44, P539, DOI 10.1007/s10600-008-9121-0 Tsuji T., 1997, Japan Patent, Patent No. [JP09124489A, 09124489] Xu XY, 2010, FOOD CHEM, V123, P1123, DOI 10.1016/j.foodchem.2010.05.073 Yang Qing, 2014, Zhongguo Zhong Yao Za Zhi, V39, P1858 Ye WC, 2001, J NAT PROD, V64, P232, DOI 10.1021/np0004451 YU SS, 1995, PHYTOCHEMISTRY, V38, P695 Zhang Y., 2018, China Patent, Patent No. [CN108129542A, 108129542] Zhao YH, 2014, FOOD CHEM, V151, P101, DOI 10.1016/j.foodchem.2013.11.030 Zhou GS, 2018, J CHROMATOGR B, V1079, P25, DOI 10.1016/j.jchromb.2018.02.002 Zhou M., 2017, DIET HLTH, V4, P341 Zong JF, 2015, FITOTERAPIA, V104, P7, DOI 10.1016/j.fitote.2015.05.001 NR 25

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0 0 1 1 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0031-9422 PHYTOCHEMISTRY Phytochemistry APR 2019 160 56 60 10.1016/j.phytochem.2019.01.002 5 Biochemistry & Molecular Biology; Plant Sciences Biochemistry & Molecular Biology; Plant Sciences HQ0RZ WOS:000462104000008 30711571 2019-04-06

PT J AU Foley, DA Burge, S Tustin, P Blackmore, T AF Foley, David Anthony Burge, Sarah Tustin, Paul Blackmore, Timothy TI Choosing wisely in infectious serology: the merits of triaging send-away tests SO PATHOLOGY LA English DT Article DE Choosing wisely; triage; send away infectious serology; cost saving ID TRAVEL MEDICINE; DIAGNOSIS; DISEASE AB Over-utilisation of pathology requests can incur unnecessary costs and be detrimental to patient care. The choosing wisely campaign has helped to reduce the use of tests with limited or no value. This report describes the estimated benefits and costs of implementing a triage process of infectious serology requests in a single mixed hospital and community laboratory. Data analysis of triaging of send away infectious serology was conducted from 1 November 2016 to 31 October 2017. A total of 618 tests were triaged over a 1-year period. Of these 379 (61.3%) were declined. The total gross savings was $45,066. The total cost for implementing this change was estimated to be $4220 per year. The total saving was $40,846.37. There was significant cost saving secondary to this intervention, with other more difficult to measure tangible benefits including fostering communication between laboratory staff and clinicians. C1 [Foley, David Anthony; Burge, Sarah; Tustin, Paul; Blackmore, Timothy] Wellington Reg Hosp, Wellington Southern Community Lab, Wellington, New Zealand. RP Burge, S (reprint author), Wellington Reg Hosp, Wellington Southern Community Lab, Dept Immunol, Riddiford St, Wellington 6021, New Zealand. EM [email protected] CR Alexander B, 2012, CRITICAL VALUES, V5, P6

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PT J AU Awin, T Mediani, A Maulidiani Leong, SW Faudzi, SMM Shaari, K Abas, F AF Awin, Tahani Mediani, Ahmed Maulidiani Leong, Sze-Wei

Faudzi, Siti Munirah Muhd Shaari, Khozirah Abas, Faridah TI Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics SO JOURNAL OF FOOD COMPOSITION AND ANALYSIS LA English DT Article DE Food analysis; Food composition; Development stages; Curcuma; Multivariate data analysis; PCA; PLS; Nuclear magnetic resonance; Biosynthetic pathway ID ESSENTIAL OIL; CHEMICAL-COMPOSITION; ZEDOARIA RHIZOMES; ANTIOXIDANT; BIOSYNTHESIS; EXPRESSION; AERUGINOSA; COMPOUND; LEAVES AB Curcuma species is a popular traditional folk medicine in India and Southeast Asia. This study aims to profile the metabolites in four Curcuma species, including C. zedoaria, C. xanthorrhiza, C. aeruginosa and C. mangga at three developmental stages (seven, eight and nine months old) using nuclear magnetic resonance (NMR)based metabolomics. Principal component analysis (PCA) showed that there are metabolites changes due to the month of harvest in each of the four species. A large quantity of curcumin and demethoxycurcumin contributed to the separation of C. xanthorrhiza, whereas the diterpenoids, such as curcumanggoside, (E)-labda8(17),12-diene-15,16-dial, calcaratarin A and zerumin B were responsible for the discrimination of C. mangga. Eight-month-old C. xanthorrhiza exhibited the highest nitric oxide (NO) inhibitory activity, while nine-month-old C. mangga exhibited the highest alpha-glucosidase inhibitory activity. The correlation among the bioactivities and phytochemical constituents was determined using partial least square (PLS) analysis. Curcumin, demethoxycurcumin, germacrone, zedoarol and xanthorrhizol were correlated with the NO inhibitory activity in C. xanthorrhiza, whereas curcumanggoside, labda-8(17),12-diene-15,16-dial and zerumin B were correlated with the alpha-glucosidase inhibitory activity in C. mangga. From the phytochemical markers and metabolic changes among growth stages of C. xanthorrhiza and C. mangga, the biosynthetic pathway was proposed to show the metabolites that might contribute to their health benefits. C1 [Awin, Tahani; Maulidiani; Leong, Sze-Wei; Faudzi, Siti Munirah Muhd; Shaari, Khozirah; Abas, Faridah] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia. [Awin, Tahani] Univ Benghazi, Fac Sci, Dept Chem, Benghazi, Libya. [Mediani, Ahmed] Univ Teknol MARA, Atta ur Rahman Inst Nat Prod Discovery, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia. [Faudzi, Siti Munirah Muhd; Shaari, Khozirah] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia. [Abas, Faridah] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia. RP Abas, F (reprint author), Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia.; Abas, F (reprint author), Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia. EM [email protected] RI Maulidiani, Maulidiani/B-3053-2019; Abas, Faridah/B-9229-2015 OI Maulidiani, Maulidiani/0000-0002-3227-4191; Abas, Faridah/0000-0002-8110-9424; Mediani, Ahmed/0000-0002-6892-1995 FU Fundamental Research Grant (FRGS) from Ministry of Higher Education Malaysia (MOHE) [5524568] FX The study was supported by Fundamental Research Grant (FRGS) from Ministry of Higher Education Malaysia (MOHE, grant no.5524568). A special thanks is extended to Mr. Tajudin, an in-house farm officer of the Institute of Bioscience, Universiti Putra Malaysia for his help in obtaining the samples. CR Abas F, 2005, J NAT PROD, V68, P1090, DOI 10.1021/np0500171 Ali K, 2011, ANAL CHIM ACTA, V703, P179, DOI 10.1016/j.aca.2011.07.036

Asghari G, 2009, RES PHARM SCI, V4, P55 Awin T, 2016, IND CROP PROD, V94, P342, DOI 10.1016/j.indcrop.2016.08.020 Bachir B, 2014, SCI WORLD J, DOI 10.1155/2014/172014 Chen SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008613 Choudhury D, 2013, INT J PHARM PHARM SC, V5, P227 Devaraj S, 2010, MOLECULES, V15, P2925, DOI 10.3390/molecules15042925 Dewick PM, 2002, NAT PROD REP, V19, P181, DOI 10.1039/b002685i Du ZT, 2011, MOLECULES, V16, P8053, DOI 10.3390/molecules16098053 Dunn WB, 2005, TRAC-TREND ANAL CHEM, V24, P285, DOI 10.1016/j.trac.2004.11.021 Garg SN, 2005, J ESSENT OIL RES, V17, P29, DOI 10.1080/10412905.2005.9698821 Ghasemzadeh A, 2016, BMC COMPLEM ALTERN M, V16, P1 Ghasemzadeh A, 2014, MOLECULES, V19, P17632, DOI 10.3390/molecules191117632 Himaja M., 2010, International Journal of Research in Ayurveda and Pharmacy (IJRAP), V1, P414 Jirovetz L, 2000, J ESSENT OIL RES, V12, P47, DOI 10.1080/10412905.2000.9712039 Jung Y, 2012, ANALYST, V137, P5597, DOI 10.1039/c2an35397k Kamazeri TSAT, 2012, ASIAN PAC J TROP MED, V5, P202, DOI 10.1016/S19957645(12)60025-X Kim HK, 2011, TRENDS BIOTECHNOL, V29, P267, DOI 10.1016/j.tibtech.2011.02.001 Kimura Y, 2013, FITOTERAPIA, V84, P163, DOI 10.1016/j.fitote.2012.11.007 Lawal U, 2015, SCI HORTIC-AMSTERDAM, V192, P400, DOI 10.1016/j.scienta.2015.06.036 Li DH, 2015, PLANT CELL PHYSIOL, V56, P843, DOI 10.1093/pcp/pcv008 Li S, 2011, PHARM CROPS, V2, P28, DOI DOI 10.2174/2210290601102010028 Makabe H, 2006, NAT PROD RES, V20, P680, DOI 10.1080/14786410500462900 Maulidiani M, 2015, PHYTOCHEM LETT, V13, P308, DOI 10.1016/j.phytol.2015.07.012 Mediani A, 2015, IND CROP PROD, V77, P602, DOI 10.1016/j.indcrop.2015.09.036 Oh OJ, 2007, ARCH PHARM RES, V30, P1236, DOI 10.1007/BF02980264 Oon SF, 2015, CANCER CELL INT, V15, DOI 10.1186/s12935-015-0255-4 Palada M. C., 2003, SUGGESTED CULTURAL P Palama TL, 2009, J AGR FOOD CHEM, V57, P7651, DOI 10.1021/jf901508f Pattanaik Bagmi, 2015, Life-Basel, V5, P269, DOI 10.3390/life5010269 Policegoudra RS, 2007, J CHROMATOGR B, V852, P40, DOI 10.1016/j.jchromb.2006.12.036 Policegoudra RS, 2010, J BIOSCIENCES, V35, P231, DOI 10.1007/s12038-010-0027-1 Singh P, 2013, FOOD BIOSCI, V3, P42, DOI 10.1016/j.fbio.2013.06.002 Singh S, 2010, EUR J MED CHEM, V45, P4379, DOI 10.1016/j.ejmech.2010.06.006 Singhal A., 2012, INT J NUTR PHARM NEU, V2, P84, DOI DOI 10.4103/22310738.95927] Sukari M. A. H., 2007, NAT PROD SCI, V13, P175 van der Sluis AA, 2001, J AGR FOOD CHEM, V49, P3606, DOI 10.1021/jf001493u Wondimu T, 2007, J ETHNOPHARMACOL, V112, P152, DOI 10.1016/j.jep.2007.02.014 Xia Z.N., 2011, J AUTOM METHOD MANAG, P18 Xie ZZ, 2009, J EXP BOT, V60, P87, DOI 10.1093/jxb/ern263 ZanarIah J., 1998, J TROP AGR FOOD SCI, V25, P225 Zhang CM, 2014, HELV CHIM ACTA, V97, P1295, DOI 10.1002/hlca.201300440 Zhang CM, 2015, PHYTOCHEM LETT, V12, P215, DOI 10.1016/j.phytol.2015.04.007 NR 44 TC 0 Z9 0 U1 5 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0889-1575 EI 1096-0481 J9 J FOOD COMPOS ANAL JI J. Food Compos. Anal.

PD PY VL BP EP DI PG WC SC GA UT DA ER

APR 2019 77 66 76 10.1016/j.jfca.2019.01.004 11 Chemistry, Applied; Food Science & Technology Chemistry; Food Science & Technology HM5MQ WOS:000459520200008 2019-04-06

PT J AU Policarpo, V Romano, S Antonio, JHC Correia, TS Costa, S AF Policarpo, Veronica Romano, Sonia Antonio, Joao H. C. Correia, Tania Sofia Costa, Suzete TI A new model for pharmacies? Insights from a quantitative study regarding the public's perceptions SO BMC HEALTH SERVICES RESEARCH LA English DT Article DE Community pharmacy; Satisfaction; Pharmacy services; Evaluation of pharmacy services; Portugal ID COMMUNITY PHARMACY; SERVICES; HEALTH; SATISFACTION; SITUATION AB BackgroundWorldwide community pharmacies are shifting their role in the healthcare system from simple medication dispensers to health care providers. High levels of satisfaction with pharmacy services were found in previous studies. This study has two main goals. The primary goal is to describe the levels of satisfaction and knowledge regarding pharmacy services in Portugal. The secondary goal is to explore the perceptions and the utilisation of pharmacy services by the Portuguese. This statement includes exploring the impact of a set of variables on both perceptions and uses of pharmacies in regard to services that are currently offered as well as to new services that may be provided in the future.MethodsA face-to-face survey of closed-ended questions was applied to a nationwide representative sample of the Portuguese population in September 2015. The sample was weighted based on population distribution across regions, habitat, age and gender. Data analysis comprises descriptive statistics and Multiple Correspondence Analysis to explore different typologies of respondent's orientation toward community pharmacy.ResultsA total of 1114 interviews comprised the study. Of the respondents, 36% used the pharmacy as a first resource when seeking to treat a minor ailment, and 54% reported that they use the pharmacy as a first resource when seeking answers about medicines. Of those who visited their pharmacy at least once in the previous year, 94% were either globally satisfied or very satisfied. The level of acknowledgement of pharmacy services' was also high among the Portuguese. Of the participants, 29% considered there could be more services available in pharmacies that are currently provided by other health care facilities. The construction of a typology of orientations towards community pharmacy practice resulted in three outcome groups: Motivated (63%), those with a connection to a pharmacy; Settled (23%), mainly those who had a pharmacy nearby; and Demobilised (14%), those who are weakly tied to a pharmacy.ConclusionsThe vast majority of the

Portuguese population has a strong positive attitude towards their community pharmacy, as expressed by the high levels of satisfaction with, and positive evaluation of, the pharmacy's services. C1 [Policarpo, Veronica] Univ Lisbon, Inst Ciencias Sociais, Av Prof Anibal Bettencourt 9, P-1600189 Lisbon, Portugal. [Romano, Sonia] ANF, Ctr Hlth Evaluat & Res CEFAR, Rua Marechal Saldanha 1, P1249069 Lisbon, Portugal. [Antonio, Joao H. C.; Correia, Tania Sofia] Univ Catolica Portuguesa CESOP, Res Ctr Publ Opin, P-1649023 Lisbon, Portugal. [Costa, Suzete] ANF, USFarm Collaborat Care Project, Rua Marechal Saldanha 1, P1249069 Lisbon, Portugal. RP Romano, S (reprint author), ANF, Ctr Hlth Evaluat & Res CEFAR, Rua Marechal Saldanha 1, P-1249069 Lisbon, Portugal. EM [email protected] FU Portuguese National Association of Pharmacies (ANF) FX This study was funded by the Portuguese National Association of Pharmacies (ANF) who contracted CESOP for the implementation of the project. Joao Antonio and Tania Correia are employed by CESOP, and Veronica Policarpo was, at the time of the study, technical director of CESOP. Sonia Romano is employed by CEFAR, the Centre for Health Research & Evaluation of ANF, and Suzete Costa was, at the time of the research, the executive director of CEFAR. The funder body (ANF) had no involvement in the design and conduct of the study or in the writing and submission of the manuscript, respecting the authors' scientific independence. CR [Anonymous], 2015, CONSUMER NEEDS FULL [Anonymous], 2012, EUR ACT PLAN STRENGT [Anonymous], 2011, GOV HLTH 21 CENT STU [Anonymous], 2015, PROGRAMA 21 GOVERNO [Anonymous], 2015, PHARM CAN NAT SURV C [Anonymous], 2016, EUROPE 2016 STATE HL, P210 [Anonymous], 2016, PHARM USAGE ATTITUDE AntAo AA, 2018, SUSTENTABILIDADE DIS Barros Pedro Pita, 2011, Health Syst Transit, V13, P1 Cavaco AM, 2005, PHARM WORLD SCI, V27, P54, DOI 10.1007/s11096-004-2129-z Costa S, 2006, ANN PHARMACOTHER, V40, P2228, DOI 10.1345/aph.1H129 Duarte A, 2007, RESPONSABILIDADE SOC Eades CE, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-582 Felix J, 2017, BMC HEALTH SERV RES, V17, DOI 10.1186/s12913-017-2525-4 Gallup, 2017, HON ETH PROF GALL HI Gomes M, 2017, REV PORT FARM, V9, P197 Hanna A, 2010, INT J PHARM HEALTHC, V4, P339, DOI 10.1108/17506121011095191 Latif A, 2016, RES SOC ADMIN PHARM, V12, P966, DOI 10.1016/j.sapharm.2015.12.007 Lee S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142269 Lynas Kathie, 2012, Can Pharm J (Ott), V145, P55, DOI 10.3821/145.2.cpj55b Martins L, 2015, HEALTH POLICY, V119, P640, DOI 10.1016/j.healthpol.2015.03.001 Martins SF, 2015, INT J CLIN PHARM-NET, V37, P896, DOI 10.1007/s11096-015-0140-1 Mehralian G, 2014, INT J CLIN PHARM-NET, V36, P707, DOI 10.1007/s11096-014-99287 MEY A, 2013, RES, V6, P281, DOI DOI 10.1007/s40271-013-0032-1 Miranda I, 2014, REV PORT FARMACOTER, V6, P3 Mossialos E, 2015, HEALTH POLICY, V119, P628, DOI 10.1016/j.healthpol.2015.02.007 Murphy PA, 2012, J AM PHARM ASSOC, V52, P67, DOI 10.1331/JAPhA.2012.10070 Nunes B, 2001, ESTUDO NACL SATISFAC, P64 Nunes FG, 2015, HEALTH EXPECT, V18, P2853, DOI 10.1111/hex.12269 Paddison CAM, 1999, NEW ZEAL J PSYCHOL, V28, P133 Panvelkar PN, 2009, PHARM WORLD SCI, V31, P525, DOI 10.1007/s11096-009-9311-2 Saramunee K, 2015, PUBLIC HEALTH, V129, P705, DOI 10.1016/j.puhe.2015.04.002

Siddiqua A, 2018, INT J PHARM PRACT, V26, P63, DOI 10.1111/ijpp.12359 Suh D C, 2000, J Am Pharm Assoc (Wash), V40, P818 Villako P, 2007, PHARM WORLD SCI, V29, P546, DOI 10.1007/s11096-007-9102-6 Whitty JA, 2015, RES SOC ADMIN PHARM, V11, P197, DOI 10.1016/j.sapharm.2014.06.007 Zhang XH, 2009, PATIENT PREFER ADHER, V3, P1 NR 37 TC 0 Z9 0 U1 0 U2 0 PU BMC PI LONDON PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1472-6963 J9 BMC HEALTH SERV RES JI BMC Health Serv. Res. PD MAR 21 PY 2019 VL 19 AR 186 DI 10.1186/s12913-019-3987-3 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA HQ2FD UT WOS:000462214600004 PM 30898124 OA DOAJ Gold DA 2019-04-06 ER PT J AU James, PB Kaikai, AI Bah, AJ Steel, A Wardle, J AF James, Peter Bai Kaikai, Angela Isata Bah, Abdulai Jawo Steel, Amie Wardle, Jon TI Herbal medicine use during breastfeeding: a cross-sectional study among mothers visiting public health facilities in the Western area of Sierra Leone SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article DE Herbal medicine; Lactation; Prevalence; Maternal health; Sierra Leone ID TRADITIONAL MEDICINE; PREGNANT-WOMEN; ANTENATAL CARE; COMPLEMENTARY; PREVALENCE; ETHIOPIA; UGANDA AB BackgroundThe use of medications, including herbal medicines during breastfeeding is always a concern among women. Currently, there is no published evidence on whether Sierra Leonean women use herbal medicine during breastfeeding. This study investigates the prevalence, correlates and pattern of herbal medicine use during breastfeeding.MethodologyWe conducted a cross-sectional study among 378 current breastfeeding mothers visiting public healthcare facilities within the Western area of Sierra Leone. Descriptive statistics and logistic regression

analysis were used for data analysis.ResultsOver a third of mothers (n=140, 37.0%) used herbal medicine during breastfeeding. However, very few herbal medicine users (2.1%, n=3) used herbal medicine to augment breastfeeding. Dietary changes were the most common method used to increase breast milk supply (93.9%, n=355) with cassava leaves sauce and tubers being the most common dietary addition. Mothers with children more than six months old were more likely to use herbal medicine than mothers with younger children (OR:1.8; CI:1.13-2.85,p=0.013). Among herbal medicine users, only 11.4% (n=16) disclosed their herbal medicine use to their conventional healthcare providers.ConclusionThe use of herbal medicine among breastfeeding mothers attending public health facilities in the Western area of Sierra Leone is common. Whilst this use is not usually specific to increasing breast milk supply, our study indicates that herbal medicines may be used to cleanse' initial breast milk. C1 [James, Peter Bai; Steel, Amie; Wardle, Jon] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Sydney, NSW 2007, Australia. [James, Peter Bai; Kaikai, Angela Isata; Bah, Abdulai Jawo] Univ Sierra Leone, Coll Med & Allied Hlth Sci, Fac Pharmaceut Sci, Freetown, Sierra Leone. [Bah, Abdulai Jawo] Univ Sierra Leone, Coll Med & Allied Hlth Sci, Fac Basic Med Sci, Freetown, Sierra Leone. [Steel, Amie] Endeavour Coll Nat Hlth, 269 Wickham St, Fortitude Valley, Qld 4006, Australia. RP James, PB (reprint author), Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Sydney, NSW 2007, Australia.; James, PB (reprint author), Univ Sierra Leone, Coll Med & Allied Hlth Sci, Fac Pharmaceut Sci, Freetown, Sierra Leone. EM [email protected] RI James, Peter/P-8492-2015 OI James, Peter/0000-0002-6373-5704 FU Faculty of Health, University of Technology Sydney FX We would like to thank the dean faculty of Pharmaceutical Science COMAHS-USL and the management of the health facilities involved in this study for creating the enabling environment for data collection. Successful completion of this manuscript was made possible through participation in the Twelve Weeks to Publication Program funded by Faculty of Health, University of Technology Sydney and with the active support and contributions made by the facilitators and other program participants. CR Abodunrin O L, 2011, East Afr J Public Health, V8, P82 Achigbu E, 2014, ORIENT J MED, V26, P107 Addo VN, 2007, J SCI TECHNOL, V27, P149 Aderibigbe S A, 2013, J Prev Med Hyg, V54, P35 Al-Sawalha NA, 2016, BREASTFEED MED, V11, P386, DOI 10.1089/bfm.2016.0044 Aleandri V, 2014, J FOOD PROCESS TECHN, V5, P2 Alwhaibi M, 2016, EVID-BASED COMPL ALT, V2016, P8 [Anonymous], 2016, SIERR LEON 2015 POP Aziato L, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1124-y Bakshi SS, 2013, ACTA TROP, V127, P46, DOI 10.1016/j.actatropica.2013.03.010 Bazzano AN, 2016, OCHSNER J, V16, P511 Birhan W, 2011, J ETHNOBIOL ETHNOMED, V7, DOI 10.1186/1746-4269-7-39 Bodeker G, 2002, AM J PUBLIC HEALTH, V92, P1582, DOI 10.2105/AJPH.92.10.1582 Budzynska K, 2012, BREASTFEED MED, V7, P489, DOI 10.1089/bfm.2011.0122 Chau CF, 2006, TRENDS FOOD SCI TECH, V17, P313, DOI 10.1016/j.tifs.2005.12.005 Chien LC, 2006, SCI TOTAL ENVIRON, V354, P120, DOI 10.1016/j.scitotenv.2005.01.033 Chuang CH, 2009, INT J NURS STUD, V46, P787, DOI 10.1016/j.ijnurstu.2008.12.015 Diaz T, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-157 Ebrahim AM, 2012, J NAT MED-TOKYO, V66, P671, DOI 10.1007/s11418-012-0630-6 Ekor M, 2014, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00177 Fakeye TO, 2009, BMC COMPLEM ALTERN M, V9, DOI 10.1186/1472-6882-9-53

Foda MI, 2004, J PEDIATR GASTR NUTR, V38, P484, DOI 10.1097/00005176-20040500000005 Frawley J, 2014, J ALTERN COMPLEM MED, V20, P571, DOI 10.1089/acm.2014.0028 Gatti L, 2008, J NURS SCHOLARSHIP, V40, P355, DOI 10.1111/j.15475069.2008.00234.x Gyasi R.M., 2011, GLOBAL J HLTH SCI, V3, P2 Gyasi RM, 2015, J ETHNOPHARMACOL, V161, P138, DOI 10.1016/j.jep.2014.12.004 Hou Y, 2006, J CHINESE MED ROC, V17, P127 Hughes GD, 2012, AFR J TRADIT COMPLEM, V9, P470, DOI 10.4314/ajtcam.v9i4.4 Jackson PC, 2010, NEONATAL NETW, V29, P225, DOI 10.1891/0730-0832.29.4.225 James PB, 2017, WOMEN BIRTH James PB, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-438 James PB, 2018, COMPLEMENT THER CLIN, V31, P7, DOI 10.1016/j.ctcp.2018.01.001 James PB, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1102-4 Jusu A, 2013, ECON BOT, V67, P299, DOI 10.1007/s12231-013-9245-4 Kaadaaga HF, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-27 Kimani-Murage EW, 2015, MATERN CHILD NUTR, V11, P314, DOI 10.1111/mcn.12161 Laelago T, 2016, ARCH PUBLIC HEALTH, V74, DOI 10.1186/s13690-016-0118-z Langlois-Klassen D, 2008, SOC SCI MED, V67, P165, DOI 10.1016/j.socscimed.2008.02.027 Lubinga SJ, 2012, AIDS CARE, V24, P1375, DOI 10.1080/09540121.2011.648600 Macfoy C, 2013, MED PLANTS TRADITION Manikandaselvi S, 2016, INT J CURR PHARM REV, V7, P151 Mann CJ, 2003, EMERG MED J, V20, P54, DOI 10.1136/emj.20.1.54 Mekuria AB, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1608-4 Mothupi MC, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-432 Nartey ET, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-65 Nordeng H, 2013, J ETHNOBIOL ETHNOMED, V9, DOI 10.1186/1746-4269-9-67 Obidah W., 2009, African Journal of Biochemistry Research (AJBR), V3, P229 Okafor IP, 2014, MALAWI MED J, V26, P45 Okoronkwo I, 2014, EVID BASED COMPLEMEN, P2014 Olisa Nwako S, 2009, Int J Pharm Pract, V17, P101 Onyiapat JLE, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-19 Pieterse P, 2015, INT HEALTH, V7, P400, DOI 10.1093/inthealth/ihv024 Ranasinghe S, 2015, J ETHNOPHARMACOL, V166, P200, DOI 10.1016/j.jep.2015.03.028 Sibeko L, 2005, J HUM LACT, V21, P31, DOI 10.1177/0890334404272388 Sim TF, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-216 Sim TF, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-317 Singh Vimal, 2004, BMC Complement Altern Med, V4, P3, DOI 10.1186/1472-6882-4-3 Steenkamp V, 2003, J ETHNOPHARMACOL, V86, P97, DOI 10.1016/S0378-8741(03)00053-9 Suroowan S, 2013, COMPLEMENT THER CLIN, V19, P36, DOI 10.1016/j.ctcp.2012.07.002 Tabuti JRS, 2003, J ETHNOPHARMACOL, V85, P119, DOI 10.1016/S0378-8741(02)00378-1 Tsai HH, 2012, INT J CLIN PRACT, V66, P1056, DOI 10.1111/j.17421241.2012.03008.x Turay BMS, 1997, MED PLANTS SIERRA LE Vickers Kathryn A, 2006, BMC Complement Altern Med, V6, P40, DOI 10.1186/14726882-6-40 WHO (World Health Organisation), 2013, WHO TRAD MED STRAT 2 Witter S, 2016, SIERRA LEONE FREE HL Zapantis Antonia, 2012, J Pharm Pract, V25, P222, DOI 10.1177/0897190011431636 Zhang Y, 2015, EVID-BASED COMPL ALT, DOI 10.1155/2015/413173 NR 67 TC 0 Z9 0 U1 0 U2 0 PU BMC PI LONDON PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND

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1472-6882 BMC COMPLEM ALTERN M BMC Complement. Altern. Med. MAR 15 2019 19 66 10.1186/s12906-019-2479-7 11 Integrative & Complementary Medicine Integrative & Complementary Medicine HP0GW WOS:000461345200002 30876454 DOAJ Gold 2019-04-06

PT J AU Moyo, P Kunyane, P Selepe, MA Eloff, JN Niemand, J Louw, AI Maharaj, VJ Birkholtz, LM AF Moyo, Phanankosi Kunyane, Phaladi Selepe, Mamoalosi A. Eloff, Jacobus N. Niemand, Jandeli Louw, Abraham I. Maharaj, Vinesh J. Birkholtz, Lyn-Marie TI Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae) SO MALARIA JOURNAL LA English DT Article DE Malaria; Gametocytes; Transmission-blocking; Artemisia afra; Sesquiterpene lactone; Natural products; Plasmodium falciparum ID HIGH-THROUGHPUT ASSAY; SESQUITERPENE LACTONES; MEDICINAL-PLANTS; MALARIA; DRUGS; DISCOVERY; GUAIANOLIDES; PRIMAQUINE; PARTHENIN AB BackgroundOptimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of transmission-blocking agents. While plant species have been extensively investigated in search of malaria chemotherapeutic agents, comparatively less effort has been channelled towards exploring them in search of transmission-blocking drugs. Artemisia afra (Asteraceae), a prominent feature of South African folk medicine, is used for the treatment of a number of diseases, including malaria. In search of transmissionblocking compounds aimed against Plasmodium parasites, the current study endeavoured to isolate and identify gametocytocidal compounds from A. afra.MethodsA bioassay-guided isolation approach was adopted wherein a combination of solventsolvent partitioning and gravity column chromatography was used. Collected fractions were continuously screened in vitro for their ability to inhibit the viability of primarily late-stage gametocytes of Plasmodium falciparum (NF54 strain), using a parasite lactate dehydrogenase assay. Chemical structures of

isolated compounds were elucidated using UPLC-MS/MS and NMR data analysis.ResultsTwo guaianolide sesquiterpene lactones, 1,4dihydroxybishopsolicepolide and yomogiartemin, were isolated and shown to be active (IC50<10g/ml; similar to 10M) against both gametocytes and intra-erythrocytic asexual P. falciparum parasites. Interestingly, 1,4-dihydroxybishopsolicepolide was significantly more potent against late-stage gametocytes than to early-stage gametocytes and intra-erythrocytic asexual P. falciparum parasites. Additionally, both isolated compounds were not overly cytotoxic against HepG2 cells in vitro.ConclusionThis study provides the first instance of isolated compounds from A. afra against P. falciparum gametocytes as a starting point for further investigations on more plant species in search of transmission-blocking compounds. C1 [Moyo, Phanankosi; Niemand, Jandeli; Louw, Abraham I.; Birkholtz, Lyn-Marie] Univ Pretoria, Inst Sustainable Malaria Control, Fac Nat & Agr Sci, Malaria Parasite Mol Lab,Dept Biochem Genet & Mic, Private Bag x20, ZA-0028 Hatfield, South Africa. [Kunyane, Phaladi; Selepe, Mamoalosi A.; Maharaj, Vinesh J.] Univ Pretoria, Inst Sustainable Malaria Control, Fac Nat & Agr Sci, Dept Chem, Private Bag x20, ZA-0028 Hatfield, South Africa. [Eloff, Jacobus N.] Univ Pretoria, Dept Paraclin Sci, Phytomed Programme, Fac Vet Sci, Private Bag x04, ZA-0110 Pretoria, South Africa. RP Birkholtz, LM (reprint author), Univ Pretoria, Inst Sustainable Malaria Control, Fac Nat & Agr Sci, Malaria Parasite Mol Lab,Dept Biochem Genet & Mic, Private Bag x20, ZA-0028 Hatfield, South Africa. EM [email protected] RI Birkholtz, Lyn-Marie/E-2939-2010 OI Birkholtz, Lyn-Marie/0000-0001-5888-2905 FU South African Medical Research Council (SAMRC) Strategic Health Initiatives Partnerships (MRC-SHIP); South African Research Chairs Initiative of the Department of Science and Technology [UID84627]; NRF [98988] FX This work was supported financially by the South African Medical Research Council (SAMRC) Strategic Health Initiatives Partnerships (MRC-SHIP) and the South African Research Chairs Initiative of the Department of Science and Technology, administered through the South African National Research Foundation (NRF) to LB (UID84627). VJM is supported by a grant from the NRF (Grant Number 98988). CR Abay SM, 2015, MALARIA J, V14, DOI 10.1186/s12936-015-0812-2 Abiodun OO, 2013, MALARIA J, V12, DOI 10.1186/1475-2875-12-43 Alonso PL, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1000406 Amoah LE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142587 Amorim MHR, 2013, CRIT REV TOXICOL, V43, P559, DOI 10.3109/10408444.2013.813905 Ashley EA, 2014, MALARIA J, V13, DOI 10.1186/1475-2875-13-418 Balaich JN, 2016, ANTIMICROB AGENTS CH, V60, P2108, DOI 10.1128/AAC.02002-15 Batista R, 2009, MOLECULES, V14, P3037, DOI 10.3390/molecules14083037 Burrows JN, 2017, MALARIA J, V16, DOI 10.1186/s12936-016-1675-x Butler MS, 2004, J NAT PROD, V67, P2141, DOI 10.1021/np040106y Clarkson C, 2004, J ETHNOPHARMACOL, V92, P177, DOI 10.1016/S0378-8741(04)00072-8 Coertzen D, 2018, ANTIMICROB AGENTS CH, V62, DOI 10.1128/AAC.02214-17;e02214-17 D'Alessandro S, 2015, ANTIMICROB AGENTS CH, V59, P5135, DOI 10.1128/AAC.04332-14 D'Alessandro S, 2013, J ANTIMICROB CHEMOTH, V68, P2048, DOI 10.1093/jac/dkt165 Duffy S, 2013, MALARIA J, V12, DOI 10.1186/1475-2875-12-408 Elfawal MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052746 Eziefula AC, 2014, LANCET INFECT DIS, V14, P130, DOI 10.1016/S14733099(13)70268-8 Forkuo AD, 2017, MALARIA J, V16, DOI 10.1186/s12936-017-2142-z Gao T, 2010, BMC EVOL BIOL, V10, DOI 10.1186/1471-2148-10-324 Gathirwa JW, 2007, J NAT MED, V61, P261, DOI 10.1007/s11418-007-0140-0 Ghantous A, 2010, DRUG DISCOV TODAY, V15, P668, DOI 10.1016/j.drudis.2010.06.002 HERZ W, 1959, J AM CHEM SOC, V81, P6088, DOI 10.1021/ja01531a065

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OA DOAJ Gold DA 2019-04-06 ER PT J AU Geldor, T Huys, I Van Dyck, W AF Geldor, Tine Huys, Isabelle Van Dyck, Walter TI Real-World Evidence Gathering in Oncology: The Need for a Biomedical Big Data Insight-Providing Federated Network SO FRONTIERS IN MEDICINE LA English DT Article DE real-world data; real-world evidence; oncology; data exploring; federated network; common data model AB Moving toward new adaptive pathways for the development and access to innovative medicines implies that real-world data (RWD) collected throughout the medicinal product life cycle is becoming increasingly important. Big data analytics on RWD can obtain new and powerful insights into medicines' effectiveness. However, the healthcare ecosystem still faces many sector-specific challenges that hamper the use of big data analytics delivering real world evidence (RWE). We distinguish between exploratory (ExTE) and hypotheses-evaluating (HETE) studies testing treatment effectiveness in the real world. From our experience and in the context of the four V's of data management, we show that to get meaningful results data Variety and Veracity are needed regardless of the type of study conducted. More so, for ExTE studies high data Volume is needed while for HETE studies high Velocity becomes essential. Next, we highlight what are needed within the biomedical big data ecosystem, being: (a) international data reusability; (b) real-time RWD processing information systems; and (c) longitudinal RWD. Finally, in an effort to manage the four V's whilst respecting patient privacy laws we argue for the development of an underlying federated RWD infrastructure on a common data model, capable of bringing the centrally-conducted big data analysis to the de-centrally kept biomedical data. C1 [Geldor, Tine; Van Dyck, Walter] Vlerick Business Sch, Healthcare Management Ctr, Ghent, Belgium. [Geldor, Tine; Huys, Isabelle; Van Dyck, Walter] Katholieke Univ Leuven, Res Ctr Pharmaceut Care & Pharmacoecon, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium. RP Geldor, T (reprint author), Vlerick Business Sch, Healthcare Management Ctr, Ghent, Belgium.; Geldor, T (reprint author), Katholieke Univ Leuven, Res Ctr Pharmaceut Care & Pharmacoecon, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium. EM [email protected] FU Vlerick Business School FX Financial support for this study was provided entirely by a grant from the Vlerick Business School. The funding agreement ensured the authors' independence in designing the study, interpreting its results, and publishing the report. CR Ardeshirdavani A, 2014, GENOME MED, V6, DOI 10.1186/s13073-014-0071-9 Berger ML, 2017, VALUE HEALTH, V20, P1003, DOI 10.1016/j.jval.2017.08.3019 Eichler HG, 2015, CLIN PHARMACOL THER, V97, P234, DOI 10.1002/cpt.59 European Medicines Agency, 2016, EMA2763762016 Ferrario A, 2015, SOC SCI MED, V124, P39, DOI 10.1016/j.socscimed.2014.11.003 Hripcsak G, 2015, STUD HEALTH TECHNOL, V216, P574, DOI 10.3233/978-1-61499-5647-574 Hughes N, 2018, EUR ODHSI S Khozin S, 2017, NAT REV DRUG DISCOV, V16, P306, DOI 10.1038/nrd.2017.26 Laney D, 2001, META GROUP RES NOTE, V6, P70

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Makady A, 2017, VALUE HEALTH, V20, P858, DOI 10.1016/j.jval.2017.03.008 Moen F, 2017, J Cancer Policy, V11, P32, DOI 10.1016/j.jcpo.2016.11.001 Onukwugha E, 2017, VALUE OUTCOMES SPOTL, V3, P6 Peeters LM, 2018, MULT SCLER J, V24, P1151, DOI 10.1177/1352458517748475 Platt R, 2009, NEW ENGL J MED, V361, P645, DOI 10.1056/NEJMp0905338 Schmidt C, 2015, NATURE, V527, pS10, DOI 10.1038/527S10a Wilkinson MD, 2016, SCI DATA, V3, DOI 10.1038/sdata.2016.18 16 0 0 1 1 FRONTIERS MEDIA SA LAUSANNE AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND 2296-858X FRONT MED-LAUSANNE Front. Med. MAR 8 2019 6 43 10.3389/fmed.2019.00043 6 Medicine, General & Internal General & Internal Medicine HO5EP WOS:000460946100001 30906740 DOAJ Gold 2019-04-06

PT J AU Rowland, CM Shiffman, D Caulfield, M Garcia, V Melander, O Hastie, T AF Rowland, Charles M. Shiffman, Dov Caulfield, Michael Garcia, Veronica Melander, Olle Hastie, Trevor TI Association of cardiovascular events and lipoprotein particle size: Development of a risk score based on functional data analysis SO PLOS ONE LA English DT Article ID LOW-DENSITY LIPOPROTEINS; PREDICTION; DISEASE; IDENTIFICATION; CHOLESTEROL; PREVENTION; SUBCLASSES; LDL AB Background Functional data is data represented by functions (curves or surfaces of a lowdimensional index). Functional data often arise when measurements are collected over time or across locations. In the field of medicine, plasma lipoprotein particles can be quantified according to particle diameter by ion mobility. Goal

We wanted to evaluate the utility of functional analysis for assessing the association of plasma lipoprotein size distribution with cardiovascular disease after adjustment for established risk factors including standard lipids. Methods We developed a model to predict risk of cardiovascular disease among participants in a case-cohort study of the Malmo Prevention Project. We used a linear model with 311 coefficients, corresponding to measures of lipoprotein mass at each of 311 diameters, and assumed these coefficients varied smoothly along the diameter index. The smooth function was represented as an expansion of natural cubic splines where the smoothness parameter was chosen by assessment of a series of nested splines. Cox proportional hazards models of time to a first cardiovascular disease event were used to estimate the smooth coefficient function among a training set consisting of one half of the participants. The resulting model was used to calculate a functional risk score for the remaining half of the participants (test set) and its association with events was assessed in Cox models that adjusted for traditional cardiovascular risk factors. Results In the test set, participants with a functional risk score in the highest quartile were found to be at increased risk of cardiovascular events compared with the lowest quartile (Hazard ratio = 1.34; 95% Confidence Interval: 1.05 to 1.70) after adjustment for established risk factors. Conclusion In an independent test set of Malmo Prevention Project participants, the functional risk score was found to be associated with cardiovascular events after adjustment for traditional risk factors including standard lipids. C1 [Rowland, Charles M.; Shiffman, Dov; Caulfield, Michael; Garcia, Veronica] Quest Diagnost, San Juan Capistrano, CA 92675 USA. [Melander, Olle] Lund Univ, Dept Clin Sci, Malmo, Sweden. [Hastie, Trevor] Stanford Univ, Dept Stat, Stanford, CA 94305 USA. RP Rowland, CM (reprint author), Quest Diagnost, San Juan Capistrano, CA 92675 USA. EM [email protected] CR Caulfield MP, 2008, CLIN CHEM, V54, P1307, DOI 10.1373/clinchem.2007.100586 Fava C, 2013, HYPERTENSION, V61, P319, DOI 10.1161/HYPERTENSIONAHA.112.202655 Greven S, 2017, STAT MODEL, V17, P1, DOI 10.1177/1471082X16681317 Hastie T, 2001, ELEMENTS STAT LEARNI Hirayama S, 2012, CLIN CHIM ACTA, V414, P215, DOI 10.1016/j.cca.2012.09.010 Johnson NB, 2014, CDC NATL HLTH REPORT KRAUSS RM, 1982, J LIPID RES, V23, P97 KULKARNI KR, 1995, J LIPID RES, V36, P2291 Melander O, 2014, CANCER EPIDEM BIOMAR, V23, P1672, DOI 10.1158/1055-9965.EPI13-1200 Morris JS, 2015, ANNU REV STAT APPL, V2, P321, DOI 10.1146/annurev-statistics010814-020413 OTVOS JD, 1992, CLIN CHEM, V38, P1632 Ramsay J., 2007, APPL FUNCTIONAL DATA SHEN MMS, 1981, J LIPID RES, V22, P236 Shiffman D, 2017, ATHEROSCLEROSIS, V263, P287, DOI 10.1016/j.atherosclerosis.2017.07.003 Sorensen H, 2013, STAT MED, V32, P5222, DOI 10.1002/sim.5989 Stone NJ, 2014, CIRCULATION, V129, pS1, DOI 10.1161/01.cir.0000437738.63853.7a Superko HR, 2008, CIRCULATION, V117, P560, DOI 10.1161/CIRCULATIONAHA.106.667428 Superko HR, 2009, CIRCULATION, V119, P2383, DOI 10.1161/CIRCULATIONAHA.108.809582 Thompson PD, 2003, CIRCULATION, V107, P3109, DOI 10.1161/01.CIR.0000075572.40158.77 van der Steeg WA, 2008, J AM COLL CARDIOL, V51, P634, DOI 10.1016/j.jacc.2007.09.060 Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837 NR 21

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0 0 0 0 PUBLIC LIBRARY SCIENCE SAN FRANCISCO 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA 1932-6203 PLOS ONE PLoS One MAR 7 2019 14 3 e0213172 10.1371/journal.pone.0213172 16 Multidisciplinary Sciences Science & Technology - Other Topics HO1AY WOS:000460638800042 30845215 DOAJ Gold 2019-04-06

PT J AU Bruggmann, D Herpe, A Quarcoo, D Schoffel, N Wanke, EM Ohlendorf, D Klingelhofer, D Groneberg, DA Mache, S AF Brueggmann, Doerthe Herpe, Anja Quarcoo, David Schoeffel, Norman Wanke, Eileen M. Ohlendorf, Daniela Klingelhoefer, Doris Groneberg, David A. Mache, Stefanie TI Descriptive review of junior OB/GYN physicians' work task financial compensation in German hospitals SO JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY LA English DT Review DE Task analysis; Job situation; Compensation; Gynecology - obstetrics ID HEALTH-CARE WORKERS; JOB-SATISFACTION; YOUNG PHYSICIANS; GYNECOLOGIC ONCOLOGISTS; REAL-TIME; TUBERCULOSIS; STRESS; OBSTETRICIANS; CONSEQUENCES; INFECTION AB Beginning in the first decade of the 21st centruy, there was a growing disregard for the benefits of the German medical system concerning the junior obstetricians/gynecologists (OB/GYN) job situation. As in other fields of medicine, numerous colleagues left Germany to work in other countries such as the United Kingdom, Noway, Sweden, or Switzerland. According to studies, financial factors

represent one of the reasons for the discontent. We here present a practical descriptive approach to assess/review the actual compensation of single work tasks of OB/GYNs on the basis of previously published, existing data. Using the workflow data from the Medical work Assessment in German hospitals (MAGRO) platform of twenty junior OB/GYNs with an average workday of 9:24:35h (SD=01:05:07h), a large scale data analysis of 2,325,556 different time points was performed to calculate the financial valuation of single work tasks. In order to assess the evolution over the past years, different modern and historic (e.g. AiP) pay scales were used and analysed in relation to the actual work on a weekly, monthly and per annum basis. Our review shows that there has been a dramatic increase in the financial reward of the practical work tasks of junior OB/GYN physicians in German hospitals in comparison to the situation of the early 2000s years. In this respect, it can not be further argued that the German system has large disadvantages concerning the payment of junior doctors in comparison to other European countries. C1 [Brueggmann, Doerthe] Goethe Univ Frankfurt, Dept Gynecol & Obtest, Theodor Stern Kai 7, D-60590 Frankfurt, Germany. [Brueggmann, Doerthe; Herpe, Anja; Quarcoo, David; Schoeffel, Norman; Wanke, Eileen M.; Ohlendorf, Daniela; Klingelhoefer, Doris; Groneberg, David A.] Goethe Univ Frankfurt, Inst Occupat Med Social Med & Environm Med, Div Social Med, Theodor Stern Kai 7, D-60590 Frankfurt, Germany. [Mache, Stefanie] Charite Univ Med Berlin, Dept Med Psychosomat, Luisenstr 13a, D-10117 Berlin, Germany. [Mache, Stefanie] Free Univ, Luisenstr 13a, D-10117 Berlin, Germany. [Mache, Stefanie] Humboldt Univ, Luisenstr 13a, D-10117 Berlin, Germany. RP Klingelhofer, D (reprint author), Goethe Univ Frankfurt, Inst Occupat Med Social Med & Environm Med, Div Social Med, Theodor Stern Kai 7, D-60590 Frankfurt, Germany. EM [email protected] CR Alami YZ, 2018, J OCCUP MED TOXICOL, V13, DOI 10.1186/s12995-018-0203-z Appel P, 2017, J OCCUP MED TOXICOL, V12, DOI 10.1186/s12995-017-0157-6 Bauer J, 2016, J OCCUP MED TOXICOL, V11, DOI 10.1186/s12995-016-0094-9 Blazek BA, 2005, AM J OBSTET GYNECOL, V193, P1798, DOI 10.1016/j.ajog.2005.08.002 Bruggmann D, 2017, J OCCUP MED TOXICOL, V12, P1, DOI 10.1186/s12995-017-0164-7 Buddeberg-Fischer B, 2005, SWISS MED WKLY, V135, P19 Buddeberg-Fischer B, 2008, INT ARCH OCC ENV HEA, V82, P31, DOI 10.1007/s00420008-0303-7 Cammu H, 2012, EUR J CONTRACEP REPR, V17, P314, DOI 10.3109/13625187.2012.672664 Cheng SM, 2018, J OCCUP MED TOXICOL, V13, DOI 10.1186/s12995-018-0192-y Cohen Jordan S, 2005, BMC Med Educ, V5, P21, DOI 10.1186/1472-6920-5-21 Cougot B, 2015, J OCCUP MED TOXICOL, V10, DOI 10.1186/s12995-015-0082-5 Diel R, 2016, J OCCUP MED TOXICOL, V11, DOI 10.1186/s12995-016-0093-x Eickmann U, 2017, ZENTRALBLATT ARB ARB, V67, P22, DOI 10.1007/s40664-016-0145-1 Elit L, 2004, GYNECOL ONCOL, V94, P134, DOI 10.1016/j.ygyno.2004.04.014 Gordinier ME, 2000, GYNECOL ONCOL, V79, P309, DOI 10.1006/gyno.2000.5954 Janus K, 2007, HEALTH POLICY, V82, P357, DOI 10.1016/j.healthpol.2006.11.003 Juranic B, 2017, J OCCUP MED TOXICOL, V12, DOI 10.1186/s12995-017-0166-5 Khabour OF, 2018, J OCCUP MED TOXICOL, V13, DOI 10.1186/s12995-018-0198-5 Kloss L, 2010, ARCH GYNECOL OBSTET, V281, P871, DOI 10.1007/s00404-009-1194-x Kordsmeyer AC, 2018, ZENTRALBLATT ARB ARB, V68, P113, DOI 10.1007/s40664-0170232-y Lojewski J, 2017, ZENTRALBLATT ARB ARB, V67, P40, DOI 10.1007/s40664-016-0155-z Mache S, 2017, ZENTRALBLATT ARB ARB, V67, P291, DOI 10.1007/s40664-017-0175-3 Mache S, 2011, EMERG MED J Mache S, 2009, LANGENBECKS ARCH SUR Mache S, 2011, J CARDIOVASC MED, V12, P475, DOI 10.2459/JCM.0b013e328347db8f Mache S, 2011, NORD J PSYCHIAT, V65, P112, DOI 10.3109/08039488.2010.504306 Mache S, 2011, JPN J CLIN ONCOL, V41, P81, DOI 10.1093/jjco/hyq152 Mache Stefanie, 2009, J Occup Med Toxicol, V4, P12, DOI 10.1186/1745-6673-4-12

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