Potensi Obat Antidepresan Yang Bersumber Dari Alga (revisi): Galih Widi Sudiro

potensi obat ANTIDEPRESAN yang bersumber dari ALGA (revisi)

Galih Widi Sudiro Pembimbing : Prof.Dr.Sumi Hudiyono PWS

LATAR BELAKANG

DEPRESI

-350.000.000 penderita -penyebab disabilitas no.2 -“tren” penyakit masa depan

Neurotransmitter monoamine Serotonin

GABA

Dopamin

Noradrenalin

Produksi

Reseptor

Re-uptake

Kerja obat antidepresan Suplemen nutrisi  Anti-oksidan  Agonis neurotransmitter  Agonis reseptor  Re-uptake inhibitor 

Produksi

Reseptor

Re-uptake

Antidepresan konvensional

Efek samping

Ketergantungan Ggn vaskular Ggn psikomotor

Aman Alami

Alga

PROSEDUR PENELITIAN

Ekstraksi

Uji toksisitas Control

• Fluoxetin • Imipramin • dll

Ujicoba hewan Test

Reverse analysis

• • • •

FST TST OFT L/D ET

: -Forced Swim Test -Tail Suspension Test -Open Field Test -Light/Dark Exploration

ALGA & ANTIDEPRESAN

Ilya Wang dkk, 2017

Sargassum horneri  β sitosterol Agonis serotonin & noradrenalin  10-30 mg/kgBB 

Forced Swim Test result

Tail Suspension Test result

Sargassum ilicifolium ekstrak kloroform & ekstrak etanol Agonis GABA, serotonin, NA  400-600mg/kgBB (ekstrak kloroform)  400mg/kgBB (ekstrak etanol) 

Solieria filiformis lectin Agonis reseptor dopamin  3-9 mg/kgBB 

Forced Swim Test result

Tail Suspension Test result

Referensi Abreu TM, Monteiro VS, Martins ABS, Teles FB, Rivanor RLdC, Mota EF, Macedo DS, de Vasconcelos SMM, Honorio Junior JER, Benevides NMB. 2017. Involvement of the dopaminergic systemin the antidepressant-like effect of the lectin isolated from the red marine alga Solieria filiformis in mice. International Journal of Biological Macromolecules (2018) 111 : 534-541.  Grosso C, Valentao P, Ferreres F, Andrade PB. 2014. Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases. Marine Drugs (2014), 12, 2539-2589; doi:10.3390/md12052539.  Wang I, Jaiswal Y, Williams L. 2017. Marine Algae as a Source of Prevention and Relief in Those with Depression and Dementia. World Journal of Pharmacy and Pharmaceutical Sciences vol 6, issue 8, 26-38.  Yende SR, Harle UN. 2013. Antidepressant-like effect of Sargassum ilicifolium in mice model of depression. Adv. Pharmacol. Toxicol. 14(3) 2013, 7-13. 

Yende SR, Harle UN, Ittadwar AM. 2016. Anxiolytic activity of marine microalgae Sargassum ilicifolium and Padina tetrastomatica in mice. International Journal of Pharmacy and Pharmaceutical Sciences vol.8, issue 5.  Yin Y, Liu X, Liu J, Cai E, Zhao Y, Li H, Zhang L, Li P, Gao Y. 2017. The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice. Royal Society of Chemistry Advances 2018, 8, 671.  Zhao D, Zheng L, Qi L, Wang S, Guan L, Xia Y, Cai J. 2016. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Marine Drugs 2016, 14, 123; doi:10.3390/md14070123  Zhen XH, Quan YC, Jiang HY, Wen ZS, Qu YL, Guan LP. 2015. Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects. Eur J Pharmacol 768:131-8 

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