Nuclear Pharmacy Syllabus - Spring 12

Syllabus s PHB BS 5971 Independ dent Study S – Introd duction to Nu uclearr Pharrmacyy

S Submitted by y:

Jeffrey J. Chrristoff, Ph.D. J J January 12, 2012 2

PHBS 5971 – Independent Study - Introduction to Nuclear Pharmacy Jeffrey J. Christoff, Ph.D. e-mail address: [email protected]

Course Description: Survey of the basic and clinical components of this specialty practice. Content includes radiation physics and exposure, exploration of the properties, regulation, preparation, and use of diagnostic and therapeutic radiopharmaceuticals that target specific systems of the body. Off campus site visits are required.

Prerequisites: P3 standing or instructor permission.

Goals and Objectives: The goal of this course is to provide the students with an introduction to nuclear pharmacy concepts in order to stimulate interest for further study of this niche practice. 1. Explain the difference between a conventional pharmaceutical and a radiopharmaceutical. 2. Discuss concepts radioactivity and the dosimetry levels associated with the medical use of radiopharmaceuticals. 3. Discuss the basic techniques of minimizing radiation exposure. 4. Explain the rationale use of diagnostic and therapeutic radiopharmaceuticals. 5. Be able to provide information to the community regarding some of the more common uses of radiopharmaceuticals. 6. Introduce the application of radiopharmaceuticals to specific disease states based on organ systems in order to stimulate interest for further study of this niche practice. 7. Become familiar with fundamental concepts related to the operation of a nuclear pharmacy including the preparation and dispensing of selected radiopharmaceuticals. 8. Become familiar with fundamental concepts related to the operation of a nuclear medicine department including procedures associated with the administration of selected radiopharmaceuticals and the methods utilized in the application of selected radiopharmaceuticals to diagnose and treat various disease states. 9. Provide a hands-on opportunity to experience routine activities in a nuclear pharmacy.

Format (2+2): 2 hours lecture per week – mostly asynchronous lectures via WebCT/MediaSite; there will be limited faceto-face lecture/discussion in the traditional classroom during the course 2 hours per lab session (HPPEC 267L) 1 site visit to an operating nuclear pharmacy is required. 1 site visit to a facility performing nuclear medicine procedures is required

Assessments: WebCT self-assessment quizzes

Site Visit Forms WebCT Exam #1 WebCT Exam #2 Laboratory Final (take home)

9 quizzes (50 points for content on Exam #1) (50 points for content on Exam #2) 25 points per completed site visit form radiation physics, instrumentation, and various basic science concepts clinical concepts of radiopharmaceuticals

100 points

50 points 100 points 100 points 50 points

Other Earned Points: Lab Assessments a. b. c. d. e. f. g. h. i. j

100 points

survey/rate meter operation (5 points) dose calibrator operation (5 points) gamma well counter operation (5 points) generator elution (5 points) MDP & CardioLite kit preparation exercises (20 points) MDP, Choletec, CardioLite and NaTcO4 quality control exercises (20 points) sterility & pyrogenicity testing (10 points) patient dose preparation (10 points) shipping containers check-in/check-out (10 points) math exercises (10 points, completed outside of lab sessions)

Total = 500 points available to be earned

Grading Penalties: Inability to document required site visits = reduction of one letter grade per occurrence

Grading Scale: A (450-500 points), B (400-449.999), C (350-399.999), F (less than 350). The grading scale may be adjusted in the student’s favor at the discretion of the course coordinator.

Textbook: - none required (one copy of the latter two texts are on reserve in the library) Nuclear Pharmacy: Concepts and Applications in Nuclear Pharmacy, 1st ed., Smith, B.T., Ed.; Pharmaceutical Press: London, 2010. ISBN: 978 0 85369 866 1 http://www.pharmpress.com ($49.99 Jan 2012) Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine, 3nd ed., Kowalsky, R.J. Falen, S.W., Eds.; American Pharmacists Association: Washington, DC, 2011. ISBN: 978-1-58212-118-5 www.pharmacist.com, Member Price: ($153.50 Jan 2012), Nonmember Price: ($191.95) with Nuclear Pharmacy Quick Reference ($159.95 Jan 2012) ISBN: 978-1-58212-151-2 Fundamentals of Nuclear Pharmacy, 6th ed., Saha, G.B. Springer-Verlag: New York, 2010. ISBN 978-1-4419-5859-4 www.springeronline.com ($89.95 Jan 2012)

The following published book chapter is posted in WebCT: Diagnostic Imaging Agents, Christoff, J. Wilson and Gisvold’s Textbook of Organic, Medicinal, and Pharmaceutical Chemistry, 12th edition, J. H. Block, J.M. Beale, Jr., Eds. Lippincott, Williams & Wilkins, 2010. Timeline: see calendar for Nuclear Pharmacy elective – Spring 2012 Didactic component Date of meeting (place) or Due Date for Assessments Thurs Jan 12 or Tues Jan 17 HPPEC 161 or RE 100 Mon 1/30 (Web CT) Mon 2/6 (WebCT) Mon 2/13 (WebCT) Mon 2/20 (WebCT) Mon 2/27 (WebCT) Wed 2/29 (WebCT) arrange 2 hour window Mon 3/19 (WebCT) Mon 3/26 (WebCT) Mon 4/2 (WebCT) Mon 4/16 (WebCT) Wed 4/25 (WebCT) arrange 2 hour window Thurs 5/10 @ 12.p.m. (take-home exam deadline)

Topic Intro to the Course - Resources for Nuclear Pharmacy Unit 1 - The Atom/Radioactive Decay Unit 2 - Radiation Safety: Practitioners and Patients Unit 3 - Production, Detection, and Quality Control of Radionuclides Unit 4 - 99mTc and Other Radiopharmaceuticals of Interest Unit 5 - PET, CT, MRI and Ultrasound Imaging Examination #1 – Basic Science Concepts (asynchronous WebCT examination) Unit 6 - Cardiovascular Imaging Unit 7 - Pulmonary & CNS Imaging Unit 8 - Skeletal/Bone Marrow, Renal, Liver/Gastrointestinal Imaging Unit 9 - Thyroid, Infection/Inflammation, and Oncology Imaging Examination #2 – Clinical Concepts (asynchronous WebCT examination) Lab Final – asynchronous, independent, written lab final (available Tues 5/1 12 p.m.)

Laboratory component (HPPEC 267L from 3:00 - 4:50 p.m. unless otherwise arranged) additional laboratory opportunities may be arranged for individual instruction provided a teaching assistant (with prior or current experience as a nuclear pharmacy intern) is assigned to Dr. Christoff as either a rotation student or as an independent study student ~ half of the class will volunteer or be assigned to the Thursday lab (Group A) ~ half of the class will volunteer or be assigned to the Tuesday lab (Group B) Date Thurs 1/12 or Tues 1/17 Thurs 1/19 or Tues 1/24

Thurs 1/26 or Tues 1/31 Thurs 2/2 or Tues 2/7 Thurs 2/9 or Tues 2/14 Thurs 2/16 or Tues 2/21 Thurs 2/23 or Tues 2/28 Thurs 3/1 spring break Tues 3/13

Topic Orientation to lab following introduction to Course in HPPEC 158 Radiation Safety Training and Demonstrations – survey/rate meters, dose calibrators, kit prep, quality control, sterility & pyrogenicity testing, dose drawing techniques – (cold lab) Practice techniques with cold materials Practice techniques with cold materials Practice techniques with cold materials Practice techniques with cold materials no lab (off to compensate for site visits) no lab (off to compensate for site visits) spring break no lab (Dr. Christoff at APhA?)

Date Thurs 3/15 or Tues 3/20 Thurs 3/22 or Tues 3/27 Thurs 3/29 or Tues 4/3 Thurs 4/5 Tues 4/10 or Thurs 4/12 Tues 4/17 or Thurs 4/19 Tues 4/24 or Thurs 4/26 Tues 5/1 or Thurs 5/3 Tues 5/8 or Thurs 5/10

Topic Hot Lab – Assessments and/or continued practice with radioactive materials Hot Lab – Assessments and/or continued practice with radioactive materials Hot Lab – Assessments and/or continued practice with radioactive materials Easter recess Hot Lab – Assessments and/or continued practice with radioactive materials Hot Lab – Assessments and/or continued practice with radioactive materials open lab if additional time is needed no lab (off to compensate for site visits) No lab - Finals week

Course Evaluations: Course evaluations will be completed as per the College’s policy and procedures.

Exam Conduct: Nonessential materials are NOT allowed at the students’ computer workstation during WebCT examinations (e.g., books, notes, note cards, PDAs or related technological devices, etc.). The student is not permitted to access any printed, electronic or other available resource of nuclear pharmacy while logged in to WebCT while completing the online examination. (**NOTE** Calculators and scratch paper/pencil are permitted) Please note the only calculator you will be permitted to use during examinations is a Casio fx300MSPlus or an equivalent calculator approved that was approved for use in the Pharmaceutical Sciences module or for the current academic year. Use of any other calculator or any other electronic device will be interpreted as evidence of dishonesty. DISHONESTY of any sort will absolutely NOT be tolerated. Violations will be addressed with the most severe of consequences allowed by the established policies of the College and the University.

Student Academic Conduct: Academic Conduct Policies are defined by the Code of Student Academic Conduct and infractions will be handled according to the policies therein. The Code may be found at: http://www.onu.edu/studentaffairs/handbook/student_handbook07.pdf

Students with Learning Disabilities In accordance with University policy, students who have a documented learning disability and require academic accommodations should contact the course instructor at the beginning of the course or as soon as possible when charged with an assignment for which an accommodation may be required. Students with learning disabilities must first verify their qualification for accommodations through Pharmacy Student Services.