Neuromuscular And Synaptic Diseases
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Disease
Symptoms
Affected Structure
Myasthenia Gravis
- Weakness - Ptosis
Ach Receptors
Botulism
Lambert Eaton Sx Black widow Poisoning Tetanus
- Accute onset - Weakness and paralysis - Blurred vision -GI symptoms - Generalized weakness - Chronic - Muscle spasm (abdomen) - Nausea - Iatrodectus fascies Muscle spasm, rigidity
Etiology Autoimmune Disease (Ab against Ach receptors)
Vesicles Toxin containing NT Inhibits cholinergic endings Presynaptic Autoimmune ++ Ca channels Disease (Ab against Ca++ channels) Ca++channels opening that increases Ach release Decrease in Ach release from inhibitory spinal cord neurons
Treatment Anticholinesterase drugs, immunosupresors, plasmapheresis, thymectomy
Special features
Antitoxin
- Canned food
Support treatment (3,4 diaminopyridine)
Chronic disease
- Ptosis - Recovery after rest
Spider bite Toxin Toxin
Antitoxin Skin Wound
Symptoms
Affected Structure
Myasthenia Gravis
- Weakness - Ptosis
Ach Receptors
Botulism
Lambert Eaton Sx Black widow Poisoning Tetanus
- Accute onset - Weakness and paralysis - Blurred vision -GI symptoms - Generalized weakness - Chronic - Muscle spasm (abdomen) - Nausea - Iatrodectus fascies Muscle spasm, rigidity
Etiology Autoimmune Disease (Ab against Ach receptors)
Vesicles Toxin containing NT Inhibits cholinergic endings Presynaptic Autoimmune ++ Ca channels Disease (Ab against Ca++ channels) Ca++channels opening that increases Ach release Decrease in Ach release from inhibitory spinal cord neurons
Treatment Anticholinesterase drugs, immunosupresors, plasmapheresis, thymectomy
Special features
Antitoxin
- Canned food
Support treatment (3,4 diaminopyridine)
Chronic disease
- Ptosis - Recovery after rest
Spider bite Toxin Toxin
Antitoxin Skin Wound
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