Gnn3 - D.w. Weener, Netherlands

Collaborative Nano Research: Key Issues & Challenges Dr. J. W. Weener MESA+ Research Institute University Twente The Netherlands GNN Workshop May 26, Saarbrucken, DE

Nanotechnology Research & Networking Regional

National

European

?

Global

What do these initiatives have in common? z

Orientation on a restricted number of strategic research goals

z

Optimal exploitation of knowledge and facilities (sharing of equipment)

z

Science-2-Industry strategy / plan

z

Joint Educational programmes

MESA+ Fact Sheet:

MESA+ • 450 people • 18 full professors • 34 M Euro turnover (55% external) • 5 Strategic Research Orientations (SRO’s): •Bionanotechnology •Nanofabrication •Molecular Photonics •Nanoelectronics •Nanofluidics MESA+TECHPARK • Centre of Innovation • 1200 M2 clean room • Central Materials Analysis Lab on-site • Office space for businesses on-site • > 25 spin-off companies on-site

DELTAMASK AQUAMARIJN NANOMI C2V TSST MICROFLOW LIONIX DANNALAB MICRONIT MEDSPRAY PHOENIX SMARTTIP MASER ENGINERING SPRENKELS CONSULTING 3T, TMF TSSE IBIS TECHNOLOGY IMMUNICOM WIWEB ………

NanoNed Fact Sheet:

Groningen/BioMade

Twente/ MESA+

Amsterdam /UvA Wageningen/ BioNano Delft/DIMES Nijmegen/NSR and -RIM TNO/TPD Eindhoven/TUe and Philips Electronics

• Dutch network in nanotechnology • Coordinator MESA+ • 8 top-level R&D Institutes in the Netherlands • National Board • 140 M Euro in Research Projects • 90 M Euro in Nanolab (NL) • Companies: Philips, Unilever, DSM, ASML, ASMI Flagships: • Advanced NanoProbing • NanoFluidics • Chemistry & Physics of Individual Molecules • Bio Nano Systems • NanoSpintronics • NanoPhotonics • NanoInstrumentation • NanoElectronic Materials • Quantum Computing • Bottom-up Nanoelectronics • NanoFabrication

Frontiers Fact Sheet:

• 12 partners • EC grant 5 M€ • Start Date: 1st August 2004 • Period: 4 years • 192 researchers & staff

Research Clusters: 1. 2. 3.

Nanofabrication Nano-Bio Interfacing Bionanotechnology Applications

• Focus: Life Sciences related Nanotechnology • Coordinating Party: MESA+ Research Institute • Industry: Unilever, Roche, C2V, BioConnect AG, others….

MANCEF Global community foundation focussed on bridging research and commercial activity. Global exposure of μn-research by bringing together: Industrials z Government representatives z Leading Practitioners in the field z Policy makers z Stakeholders z End users z Equipment Suppliers z Financial experts z Customers z Education z

Information: www.mancef-coms2005.org

Micro-Nano Roadmap

13 April, 2005, Munich, DE

Studying Global Nano-micro Centers Turkey; 1 Italy; 1 United Kingdom; 1 France; 1 Switzerland; 1 Sweden; 1

9 Starting point for a global picture of national initiatives and ambitions

Japan; 1 Netherlands; 2 Taiwan; 2 European Union; 2

China; 4

USA; 31

9 Centers are focal points of technological excellence Korea; 8

9 Identifying different types of centres and initiatives First results will be published at:

Germany; 11

21-25 August 2005 Contact: [email protected]

Network of Excellence

Purpose: Integrating the critical mass of expertise needed to provide European leadership. Main deliverable: Durable structuring of how research is carried out in Europe and spreading of excellence. Challenge: Overcome organizational, human and cultural barriers.

Frontiers’ Aim

Peripheral

Core

Peripheral

Core

Core

Core Partner 5

Partner 1

Partner 5 Partner 1

Peripheral Core

Core

Partner 2

Core

Core

Peripheral Partner 4

Core Peripheral

Partner 4

Partner 2

Core

Partner 3 Partner 3

From Isolated Centers to a Coherent Network

Frontiers’ partners: 1

Mesa+ Research Institute, NL

2

University of Aarhus, DK

3

University of Cambridge, IRC in Nanotechnology, GB

4

Technical University Delft, dep. NanoScience, NL

5

Interuniversitair Micro-Elektronica Centrum, BE

6

Forschungszentrum Karlsruhe GmbH, DE

7

CeNTech GmbH, DE

8

Chalmers University of Technology, SE

9

National Centre of Competence for Nano Science, CH

10

Max Planck Institute for Solid State Research, DE

11

Nano Science Group CEMES/CNRS, FR

12

Westfalian Wilhelms University Münster, DE

Key Elements Frontiers: a 4-legged strategy

WP1

Virtual European Nano-sciences Laboratory

WP2

Coordination of Research

WP3

European Joint Curriculum

WP4

Spreading of Excellence

TOP-DOWN APPROACH

Research Collaborations (I)

Enschede, NL, August 22-24, 2004 Three research clusters were defined: 1. Nanofabrication of Single Molecules and Individual Nanoclusters 2. Nanobio Interfacing 3. Life-sciences and Nano Applications

Cluster I Nanofabrication of Single Molecules / Nano-clusters

General: * Top / down Lithographic Techniques and Bottom-up Self-assembly * Cluster I creates the technology Platform for Clusters II and III

Competencies Identifiable: • Measurement Tools to Probe Single Molecule Interactions • Self-assembly / Self-organization • Functionalization of Surfaces and / or Probes • Surface Structuring at Nano-scale • Manipulation Techniques: Nanoneedles, Probes, Optical Tweezers • Detection: Surface Plasmon Resonance (SPR), Near Field Optical Microscopy, Atomic Force Microscopy (AFM) • Fine structuring and / or deposition with: Nanostenciling Techniques, Ultra High Resolution Inkjet printing and Focused Ion Beam Tools • Other…..

Cluster II Nano-Bio Interfacing General: * Formation of Bio-Nano Hybrid Structures * Utilize High Sensitivity and High Selectivity of Biological Material 4 Sub-clusters have been defined: 1. Support Structures for Bio-Molecules Immobilization of Biomolecules at well defined Surfaces: Biocompatible, Semi Conducting, other…..

2. Manipulation of Single Bio-Molecules Positioning of Bio-Molecules through: Surface Morphology, Mechanical Movement,…

3. Addressing Bio-Molecular structures Development of Techniques to address Bio-Molecules Individually and Selectively: Grid-like Addressing, other…

4. Advanced Probe Microscopy Techniques Investigation of Biological Nanostructures Manipulation of Surfaces (at nm-scale) Bio/Nano Hybrid sensors

Cluster III Life Sciences and Nano Applications General: Focus on Bio-Nanotechnology Applications Lab-on-Chip systems, Nanomedicine, other.. 4 Sub-clusters have been defined: 1. Drug-Delivery Nanoparticles Obstacles to deal with: Half-life of the Drug, Cell Recognition, Efficient Intracellular Delivery, Other…

2. Biocompatibility Focus at Bio-Integration of Artificial Materials (Implants): Chemical Properties of Implant Topographical Properties of Implant Critical Molecular Interactions at Bio-Interface

3. Cell Control Gain Control over Tissue Development through Cell Control

4. Biosensing Development of Ultra-sensitive Nano-Biotechnological Molecular Recognition Devices

BOTTOM-UP APPROACH

Research Collaborations (II) Aarhus, DK, November 22-23, 2004 31 research focus areas were defined by participants

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Drug delivery nanocarriers Biocompatibility of implant materials Nano-channels Lab-on-a-chip and microfabrication Surface patterning (polymer-based, bilayers) Self assembly (synthetic and biomolecules, nanowires 3D fabrication and assembly

-

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Nanopores and molecular recognition Nanoparticles as sensors Molecular machines and motors Single molecule fluorescence imaging and spectroscopy Single molecule manipulation techniques (SPM, OT, MT, magnetic beads Mass spectroscopy on single cells X-ray microscopy

Research Collaborations (III) 1

2

3

MESA+

X

X

X

Aarhus

X

4

5

6

7

8

X

X

X

X

X

X

Muenster

X

Chalmers

X

12

X

X

X

X

X X

X

X

X X

Cambridge X X

CEMES

Karlsruhe

11

X

NCCR

Max Planck

10

X

IMEC

TU Delft

9

X

X

X X

X X

Merging top-down & bottom-up 2. Nanopore as functional platform

Cluster 1 (MESA+) Nanofabrication of single molecules and individual nanoclusters

5. Single cell mass spectroscopy 11. Patterning light guides on the surface 12. Nanofabrication

3. Coupled plasmon affinity biosensor

Cluster 2 (Karlsruhe) Nano-bio interfacing

4. Cadherins interacting with cells 6. Cantilevers

1. Trafficking and disassembly of dd systems 7. Optical detection and nanochannels

Cluster 3 (Aarhus) Life sciences and nano applications

8. Wetting of nanochannels 9. Nanotechnology based targeted dd 10. 3D nanopore scaffolds for drug delivery

Coordination of Research Network Concept Map

Cluster Concept Map I

Cluster Concept Map II

Entity Concept Map

Entity Concept Map

Entity Concept Map

Entity Concept Map

Entity Concept Map

Entity Concept Map

Research Projects

Cluster Concept Map III

Frontiers’ Frontiers Meeting Schedule

Months 0

3

Project start, Kick-off Meeting

X

Strategic Research Cluster Meetings

X

Frontiers’ Management Committee Meetings Governance Board Meetings

6

9

12

X X

15

18

X X X

X

Management Involvement Mesa+

Aarhus

Cambridge

Virtual laboratory

TU Delft

IMEC

Karlsruhe

CeNTech

Chalm ers

Lead

Coord. Research

Lead

Cluster 1

Lead

Cluster 2

Lead

Cluster 3

Lead

Joint Curriculum

Lead

Science-toindustry

Lead

Org. & Mgt.

Lead

External Communication

Lead

Gender Issues

Lead

Ethics

Lead

NCCR

Max Planck

Toulouse

Münster

Collaborative Nano Research: do’s and don’ts Partners

• find the optimum number of partners that are willing to integrate & commit themselves to the research program • identify each others core competencies and peripheral activities at an early stage • every partner needs to see the added value of integration • spread the tasks evenly over the partners • valuable research collaborations are only possible once the partners have in depth knowledge of each others research activities

Collaborative Nano Research: do’s and don’ts Management

• keep the focus on a limited number of ‘flagships’ in research • try and keep the balance between science and administration for researchers • set-up a management structure that can effectively follow up on research collaborations • top-down approach does not work in setting up research collaborations • management should be: strict and flexible at the same time

Collaborative Nano Research: do’s and don’ts Meetings

• organize research meetings on a regular basis, but not too often! • try and alternate meetings between partners / locations • meet preferably face-to-face • make sure all partners are actively involved in research meetings

The process of collaborative nano-research A bottom-up self-assembly process: Once you’ve put the right information in the molecules the self-assembly process is spontaneous because it is energetically favored

Integration 1) Reactants (partners) 2) Stir (Regular meetings) 3) Solvent (Facilitating management) 4) Reaction time (Patience) 5) Product Yield (Solid Network)