Formulario_farmacocinetica.docx
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Formulario farmacocinΓ©tica
Modelo bicompartimental:
Modelo monocompatimental:
Cp=Ae-Ξ±t + Be-Ξ²t
lnC= lnCo-kt
K12=
π΄π½+π΅πΌ π΄+π΅
K10=
πΌπ΅ π21
t1/2= ln2/k π·ππ ππ ππ
Vd=πΆπ ππ/ππΏ
K12=Ξ±+Ξ²-(k10+k21)
ExcreciΓ³n urinaria:
Donde:
Se grafica t
βππ₯ ln βπ‘
vs tmid acumulado
[]mg/mL vol
n.. nβ¦
nβ¦
A= [periferico] Ln(
[] x vol
βππ₯ βπ‘
nβ¦
nβ¦
nβ¦
Ξex
Ξt
βππ₯ ) βπ‘
B= [Central] Formulas multidosis:
nβ¦
πΆπππ₯
Tmax=1.44 (t1/2)*ln πΆπππ Kex=
πππ ππ ππ₯πππππΓ³π π·ππ ππ
1.44(π‘1/2 )
R=
π‘ πππππ‘πΆπππ πΉ
Dm= Bioequivalencia: ABC=
πππΉ
πππΆπππ₯
t= ππ = πΆπππ/ππ βπππ‘
[π΄π΅πΆ]π΄ πππ ππ π΄ Frel= π₯ [π΄π΅πΆ] π΅ πππ ππ π΅
Modelo abierto de un compartimento con infusiΓ³n constante: Cp=Cpo e-ket+ Cpee(1-e-ket) Ko=(Ke) (Vd)( Cpee) Cpβ =(Cpee)(e-ket) Cl=(Ke)(Vd) Vd=
πΎπ πΎππΆπππ
Ln[Cpee-Cβ]=ln(Cpee-ket) Cpee-Cpβ=Cpeee e-ket Ko=Ke * Acee Donde: Ko: constant de velocidad de infusiΓ³n Cpo: Cp en tiempo cero
πΉπ·π Cminee= ππ(1βπ βπππ‘ )
Cmaxee= Cpee=
πΉπ· ππ(1βπ βπππ‘ ) πΉπ·
πππππ‘
Modelo bicompartimental:
Modelo monocompatimental:
Cp=Ae-Ξ±t + Be-Ξ²t
lnC= lnCo-kt
K12=
π΄π½+π΅πΌ π΄+π΅
K10=
πΌπ΅ π21
t1/2= ln2/k π·ππ ππ ππ
Vd=πΆπ ππ/ππΏ
K12=Ξ±+Ξ²-(k10+k21)
ExcreciΓ³n urinaria:
Donde:
Se grafica t
βππ₯ ln βπ‘
vs tmid acumulado
[]mg/mL vol
n.. nβ¦
nβ¦
A= [periferico] Ln(
[] x vol
βππ₯ βπ‘
nβ¦
nβ¦
nβ¦
Ξex
Ξt
βππ₯ ) βπ‘
B= [Central] Formulas multidosis:
nβ¦
πΆπππ₯
Tmax=1.44 (t1/2)*ln πΆπππ Kex=
πππ ππ ππ₯πππππΓ³π π·ππ ππ
1.44(π‘1/2 )
R=
π‘ πππππ‘πΆπππ πΉ
Dm= Bioequivalencia: ABC=
πππΉ
πππΆπππ₯
t= ππ = πΆπππ/ππ βπππ‘
[π΄π΅πΆ]π΄ πππ ππ π΄ Frel= π₯ [π΄π΅πΆ] π΅ πππ ππ π΅
Modelo abierto de un compartimento con infusiΓ³n constante: Cp=Cpo e-ket+ Cpee(1-e-ket) Ko=(Ke) (Vd)( Cpee) Cpβ =(Cpee)(e-ket) Cl=(Ke)(Vd) Vd=
πΎπ πΎππΆπππ
Ln[Cpee-Cβ]=ln(Cpee-ket) Cpee-Cpβ=Cpeee e-ket Ko=Ke * Acee Donde: Ko: constant de velocidad de infusiΓ³n Cpo: Cp en tiempo cero
πΉπ·π Cminee= ππ(1βπ βπππ‘ )
Cmaxee= Cpee=
πΉπ· ππ(1βπ βπππ‘ ) πΉπ·
πππππ‘
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