Che 426n Obe Course Syllabus Ver 2018-2019.docx

COURSE SYLLABUS 2nd

Semester, AY 2018-2019

Course Information

Faculty Information

Course Code: Course Title: Credit Units: Pre-requisites: Schedule:

Name: Office: Email: Phone: Consultation Time:

CHE 426N Introduction to Biotechnology 2 CHEM 31 Organic Chemistry II 5:00 – 6:00 PM TTH (LBCH1TC)

Engr. May V. Tampus Department of Chemical Engineering [email protected] (032)3446783 See posted schedule on department bulletin board.

Course Description This course will provide you a brief treatment of the foundations of biotechnology and some of its present and future uses. This will also give you the fundamental science behind molecules of life. Attention will be given on the chemistry and biology of cells, metabolism, and enzymes. Also, the course will briefly introduce cell and enzyme kinetics and bioreactors. COURSE OUTCOMES (CO) By the end of the semester, you should be able to: Alignment to Program Outcomes CO1: explain the structure, organization, function, The course is enabling to your achievement of: genetics and metabolism of living matter in molecular [PO1] ability to apply knowledge of mathematics and terms; science to the general practice of chemical engineering CO2: define the role of living cells (and the substances and in at least one specialized field of application; and derived from them) in some biochemical reactions [PO5] ability to identify, formulate, and solve chemical occurring in nature; engineering problems. CO3: critique current methods/techniques for the production of commercially important biochemical The course is introductory to your achievement of: products; and [PO9] Ability to engage in life-long learning and to update CO4: apply the principles governing cell and enzyme oneself continuously with the current trends and kinetics in solving bioreaction problems. development in a chosen field of specialization; and [PO10] Understanding of the broad economic, environmental, societal and global impacts of chemical engineering solutions. ASSESSMENT OF OUTCOMES Your level of achievement of the outcomes shall be evidenced by the quality of your outputs and your performance in tests and exams. Formative For CO1 – CO4: Seatworks & Assignments (SA)

Summative (Rubric-Based) For CO1: Molecules of Life Picture Album (PA) For CO2: Role Play on Metabolism (RP) For CO3: Paper Critique (PC) For CO4: Final Examination- Cell & Enzyme Kinetics and Bioreactors (FE)

Specific guidelines for the preparation and submission of each summative output will be provided in class. Assessment & Evaluation Rubrics (See Annex) Output/Performance Molecules of Life Picture Album Report (PA) Paper Critique (PC) Role Play on Metabolism (RP) Final Examination- Cell & Enzyme Kinetics and Bioreactors (FE)

Rubric Number and Title [CHE426N-1] Picture Album Report Rubric [CHE426N-2] Paper Critique Rubric [CHE426N-3] Role Playing Rubric [CHE426N-4] Answering Numerical Problems Rubric

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines

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Portfolio of Seatworks & Assignments (AS)

Grading System Your grade for the course is computed based on both formative and summative assessment data. The computation is detailed below. Grade Component AS Grade FE Grade PA Grade PC Grade RP Grade

Weight (10%) (40%) (15%) (20%) (15%)

Computation AS Grade FE Grade PA Grade PC Grade RP Grade Total

x 0.10 x 0.40 x 0.15 x 0.20 x 0.15 Grade

Passing Grade: 3.0 Condition for Passing: FE Grades must be 3.0 or better. LEARNING PLAN Course Outcome ---

CO1 CO2

CO1 CO2

CO2 CO3 CO4

Topics

Week

Introduction to the Course Chemistry and Biology of Cells  History of Biotechnology  Cellular basis of life  Organization of cells  Biomolecules  Chemical Forces Important Biomolecules  The Structure of DNA  The Flow of Biological Information Cellular Metabolism  Carbohydrate Metabolism  Protein Metabolism  Fat Metabolism MIDTERM EXAM WEEK

1

Learning Activities     

2–5 to

Enzyme and Enzyme Kinetics  Introduction  Simple Enzyme Kinetics  Inhibition of Enzyme Reactions  Factors Influencing Enzyme Activity  Industrial Application of Enzymes

6–8 9 

 

Interactive Discussion Exercises: Issues on the risk and new technology  Role Playing Submission of Picture Album   

10 - 13 

CO2 CO3 CO4

Cell Kinetics and Bioreactors  Introduction and Definition of Terms  Growth Cycle for Batch Cultivation  Laboratory and Industrial Bioreactors  Industrial Application of Cells FINAL TERM EXAM WEEK

Open forum re Course Syllabus Interactive Discussion Interactive Discussion Exercises: Issues on the risk and new technology Picture Search

14 - 17

18 

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines

  

Interactive Discussion Calculation Workshop Reading and Paper Critique: Roles of Enzyme and the Methods/Techniques of Commercially Important Biochemical Products Final Examination on Enzyme and Enzyme Kinetics Interactive Discussion Calculation Workshop Final Examination on Cell Kinetics and Bioreactors

Submission of Paper Critique

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Learning Resources Books 1. Bourgaize D, Jewel TR and Buiser RG. Biotechnology (Demystifying the Concepts). Addison Wesley Longman, INC. 2000. 2. Shuler ML and Kargi F. Bioprocess Engineering Basic Concepts. Prentice-Hall, Inc. NJ, 2002. 3. Lee J. Biochemical Engineering. John Wiley and Sons, USA, 1995. Note: Numerous books dealing on biotechnology can be found at the Learning Resource Center. Ask the help of our librarian. Course Policies Molecules of Life Picture and Paper Critique Team You are to form a project team of up to three members to work on presenting a picture album on the molecular structure of different types of cells and its components. The groups are to submit a written report containing the said picture collection during the midterm week. Compilation of the said picture album can be softbound or fastened in a short folder. For the paper critique report, this will be on the second half of the semester. The teams are allowed up to Week 9 to decide what specific topic/product they will work with. By Week 10, you must already inform the instructor of the final topic. The content should focus on the roles of cells and the substances (e.g. enzymes) derived from them and the new methods/techniques used for the commercial production of biochemicals. At least 15 published research papers will serve as references. Written report should be submitted during the final week in a softbound copy. Aside from the hardcopy for the two course requirements, please submit a softcopy (in CD) to the instructor. Attendance and Tardiness You are required to attend all classes. The policies in the USC Student Manual (Current Edition) shall be followed. Coming to class on time is also required. If you are more than 15 minutes late, do not anymore enter the classroom. You are only allowed three instances of up to 15-minute tardiness for the entire semester. Once you have reached that allowed number, you will no longer be allowed to come inside the classroom late, even if you are only 1-minute tardy. Tests and Examinations No make-up will be given for missed long tests as these tests are only formative in nature. If you are not able to take any of the two final examinations on the scheduled date, you can make a formal written request to take a make-up examination but only in cases when you missed an examination due to serious medical condition or personal emergency. Pertinent supporting documents must be attached to your letter of request. Any request stands both chances of getting granted or denied. The instructor shall be the one to set the date and time of the make-up exam. Timely Submission of Required Outputs Indicated in the learning plan above are the weeks when the two required outputs (PA and PC) are respectively due. The exact date and time of the submission deadline will be announced a week before. Outputs submitted beyond the deadline will not be accepted and will automatically lead to an INC rating for the course. To complete the INC, new equivalent tasks will be required. Communication All course-related communications outside of class should be done through the course email [email protected]. Supplementary learning materials, announcements, instructions and the like will be through such email. Make sure that you regularly check your inbox. Use of Gadgets in Class Gadgets should only be used in class in aid of learning. It may be allowed that you go online in the classroom if you want to find out more about the topic being taken up. In no way that you are allowed to use your gadgets in class to do social networking, games, or other activities that have no direct bearing on the ongoing class activity. At all times, set your gadgets on silent mode.

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines

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Prepared by

: _____Engr. May V. Tampus_______________ (Name in print & signature of Faculty Member)

Approved by : _____Engr. Luis K. Cabatingan

________

(Name in print & signature of Department Chair)

Date Approved: ____________________________________ Annex (CHE 426N: Introduction to Biotechnology)

[ChE 426N-1] Picture Album Report Exceeds Expectations

Meets Expectations

1.0-1.3 2.0 Picture Collection & Presentation (40%) It is very obvious what the It is fairly obvious what picture collection features; the picture collection the collection shows clearly features; the collection the structure, organization, shows the structure, function, genetics and organization, function, metabolism of living matter; genetics and metabolism of labels are effectively used; living matter; labels are all sources are properly used; all sources are credited. properly credited. Picture Descriptions (60%) The accompanying text describes in concise full detail the underlying principle or innovative idea (behind the design of the equipment, equipment part or material) as captured in the pictures.

The accompanying text describes some detail about the underlying principle or innovative idea behind the design of the equipment, equipment part or material; there are a few mismatches with the description and what the pictures are able to show.

Partially Meets Expectations 3.0

Does Not Meet Expectations 4.0

It requires some time to identify what the picture collection features; the collection vaguely show the structure, organization, function, genetics and metabolism of living matter; labels are used but can be better done; some sources are not properly credited.

It is unclear what the picture collection features; the collection does not show the structure, organization, function, genetics and metabolism of living matter; labels do not aid understanding of the picture; sources are not credited.

The accompanying text gives a sketchy general remark about an underlying principle or innovative idea behind the design of the equipment, equipment part or material; however, the description does not show a good match with the pictures presented.

The accompanying text does not describe any underlying principle or idea about the design of the equipment, equipment part or material shown in the pictures.

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines

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[ChE 426N-2] Paper Critique Rubric Exceeds Expectations

Meets Expectations

1.0-1.3 Summary (20%) Well-written summary of the article that provides a clear description of the article leaving no question of the contents.

2.0

Partially Meets Expectations 3.0

Does Not Meet Expectations 4.0

Well-written summary of the article that provides a clear description of the article but leaves some questions as to the contents.

Summary of the article that Not providing a summary of is either not clear or leaves the article’s contents. several questions as to the contents.

Writing shows an average understanding of the concepts behind the role of the microorganisms (and/or the substances derived from them) as presented in the article.

Writing shows a below average understanding of the concepts behind the role of the microorganisms (and/or the substances derived from them) as presented in the article.

Writing shows a poor understanding of the concepts behind the role of the microorganisms (and/or the substances derived from them) as presented in the article.

Interpretation is either incorrect or not supported by appropriate arguments with regards to the new insight(s), methods or techniques for the production of commercially important biochemical Connected most the products. contents of the articles to Thoroughly connected the other concepts learned. Connected most the contents of the articles to contents of the articles to other concepts learned. other concepts learned. Grammar and Spelling (10%) Writing clear enough to Errors detract somewhat, Writing is excellent. support a clear but there seems to be No errors. understanding of the general understanding of paper’s content. the paper’s content.

Interpretation is clearly incorrect or you have made no attempt to think deeply about the concepts presented in the article.

Criticism (70%) Writing shows a deep understanding of the concepts behind the role of the microorganisms (and/or the substances derived from them) as presented in the article. Interpreted, analyzed, and described new insight(s), methods or techniques for the production of commercially important biochemical products not considered before in a clear and coherent manner.

Interpreted and analyzed new insight(s), methods or techniques for the production of commercially important biochemical products in a fairly clear and coherent manner.

One or two errors.

Described the content of the article and have not thought deeply about it.

Errors make reading difficult, if not impossible to comprehend. More than five errors.

More than two errors but less than six.

[ChE 426N-2] Presentation Rubric Criteria

Exceeds Expectations (1.0-1.3)

Meets Expectations (2.0)

Knowledge/ Understanding

Knowledge of topic is exceptionally accurate and is explained clearly and effectively during explanation using details of the fundamental principles, relevant theories and concepts; There is little reliance on notes Very clear & concise flow of ideas

Issue is accurately explained and uses many details and various sources in presentation with some reliance on notes.

Delivery & Enthusiasm

Clear flow of ideas; Demonstrates interest in topic & engagement with the class

Partially Meets Expectations (3.0) Issue is explained with some accuracy but need more details and more variety in sources and less reliance on notes.

Did Not Meet Expectations (4.0) Issue requires more accurate information and details or examples; Heavy reliance on notes during presentation.

Most ideas flow but focus is lost at times;

Hard to follow the flow of ideas; Lack of enthusiasm & interest

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines

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Visuals

Demonstrates passionate interest in the topic & engagement with the class; Very clear enunciation & rate of speed is appropriate; Speaker makes eye contact with everyone and has no nervous habits; Speaker has excellent posture

Clear enunciation & rate of speed is appropriate most of the time; Speaker sometimes makes eye contact with the audience; Mildly distracting nervous habits are present but do not override the content

Visuals augment and extend comprehension of the issues in unique ways

Use of visuals related to the material

Limited evidence of interest in & engagement with the topic Sometimes clear enunciation & rate of speed is appropriate some of the time; Speaker makes eye contact with only a selected few; Nervous habits sometime distract the audience Limited use of visuals loosely related to the material

Many blunders in enunciation & rate of speed is either too fast or too slow; Very little or no eye contact is made with the audience; Speaker is reading the presentation; Nervous habits distract the audience No use of visuals

[ChE 426N-4] Answering a Numerical Problem Exam Rubric 1.0-1.3

2.0

3.0

4.0

Outstanding

Competent

Marginal

Not Acceptable

Criteria 

All givens necessary for solving the problem are stated along with correct units; givens noted in the problem statement but not necessary for solving the problem are eliminated.

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All givens necessary for solving the problem are stated along with correct units; some irrelevant givens are also listed. Some givens are confused with assumption.

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Problem statement is clear and thorough with all variables required for solving the problem clearly indicated.

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Problem statement is clear but some requisite variables for solving the problem is not indicated.

Given and Assumptions

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Interpretation of the problem and schematic diagram (If appropriate)

Assumptions are completely listed, valid, justified.

A complete and clear schematic of the system being described is provided and properly labeled.

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Assumption completely listed and valid. In some cases not clearly justified but are clearly implied in the calculation section.

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Relevant schematic is provided but some information (state and condition) and labels (dimensions and variables) as described in the problem are missing, but would not hinder the assessment of the system described.

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All givens necessary for solving the problem are stated along with units; irrelevant givens are also listed. Givens are confused with assumption.

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Givens are listed but incomplete; irrelevant givens are listed, or givens are stated without accompanying correct units. Givens are confused with assumption.

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Problem statement is ambiguous and/or misses to indicate critical unknowns required.

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Most assumptions are missing. Assumptions listed are mostly valid but not justified or simply implied in the calculation section.



The provided schematic is either ambiguous or incomplete, hindering the assessment of the system described in the problem.

Problem statement is clear but important variables for solving the problem are not indicated.

Some assumptions are missing or confused with givens. Assumptions are valid although in some cases not clearly justified, but implied in the calculation section. Relevant schematic is provided but important information (state and condition) and labels (dimensions and variables) as described in the problem are not provided, hindering the assessment of the system

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines

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described in the problem. 

All relevant governing equations are given in full form

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Equations are properly reduced according to assumptions and mathematically manipulated correctly to solve for unknown on the left in terms of known on the right (if possible).

Analysis and Solution 

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Steps in the analysis are easy to follow. Unit conversions are explicit and correct.

Results are clearly indicated, error-free and thorough.

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All key equations are provided are mostly in reduced form.

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Correctness of result is judged. Validity of answers in terms of assumptions is discussed. “What if” scenarios are considered.

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Some key equations are missing, erroneous or reduced form of governing equations are given.

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Some errors exist in the reduction and mathematical manipulation.

Equations are mathematically manipulated correctly to solve for unknown on the left in terms of known on the right (if possible).

Steps in the analysis are easy to follow.

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Solution is difficult to follow.

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Unit conversions are correct but not clearly shown

Unit conversions are explicit and correct.

Results are clearly indicated, correct and thorough.

Results and Interpretations (When necessary)

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Correctness of result is judged. Validity of answers in terms of assumptions is discussed.

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Results are given but not clearly highlighted, or some key results are missing, or some are erroneous.

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Correctness of result is judged. Validity of answers in terms of assumptions is discussed.

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines

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Most key equations are missing or erroneous.

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Many errors exist in the reduction and mathematical manipulation.

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Solution is messy and not possible to follow

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Error in the conversion of units. Results are incomplete, wrong or difficult to identify.

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Erroneous results are improperly judged to be reasonable, or assumptions not reflected upon.

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