Cable Resume 040809

Edward E. Cable, Ph.D. 17239 Grandee Place San Diego, CA 92128

Updated 04/09

(858) 603-0855 (c) [email protected] SUMMARY

Highly experienced, creative scientist and emerging leader, with a demonstrated record of sustained success in drug discovery and academic science. A collaborative investigator who enjoys the challenge of identifying and implementing novel and challenging research projects with the potential to address unmet medical needs. An engaging communicator, equally comfortable interacting with academic and pharmaceutical scientists, other functional specialists – including physicians – and executives. • • •

Evaluation, selection and implementation of internally identified research opportunities Established multiple academic and business partnerships Preclinical team leadership and clinical development team participation

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Due diligence and evaluation of external projects for in-licensing opportunities Successful in acquiring funding from NIH and other sources Published author of more than 30 peer-reviewed manuscripts, and numerous reports and presentations

QUALIFICATION HIGHLIGHTS Strategic Communication Experience • As the MB07811 project leader, authored or co-authored internal document in support of the development of MB07811 for the treatment of elevated LDL cholesterol. Document package included scientific rationale, preclinical efficacy and safety pharmacology data, regulatory strategy and hurdles, projected patient populations and market analyses including marketed and potential treatments currently in development • Represented MB07811 in peer reviewed manuscripts, national meetings and internal consultant and Key Opinion Leader (KOL) meetings • Developed numerous non-confidential summaries for potential out-licensing efforts • Served as advisor on in-licensing opportunities and competitor analyses • Authored numerous white papers and Strength, Weakness, Opportunities and Threats (SWOT) analyses for different therapeutic areas Therapeutic/Scientific Area Experience • Extensive background in metabolic diseases and integrative physiology • Systems biology approach to research and eagerness to implement the use of new technology to gain fundamental insights

Edward Cable

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Resume

Broad-based understanding of pharmacokinetic and pharmacodynamic principles for small molecules and macromolecular therapeutics Designed an implemented various technologically challenging assays including enzyme, protein/RNA interaction, cell based transporter and in vitro pharmacology assays

Management Experience • Developmentally-oriented project manager • Matrix team and cross-functional, permissive democratic leader who seeks the best possible solution • Experience in developing effective and efficient research programs to generate go/no-go decisions BD/IP Experience • Identified and recruited KOL’s and CRO’s to contribute to projects • Analyzed market opportunities and commercial viability of metabolic disease targets including different therapeutic intervention strategies and IP space • Evaluated and identified key IP spaces with freedom to operate for nuclear receptor agonists, treatment of hepatic steatosis and novel peripheral treatments for obesity • Due diligence evaluating in-licensing opportunities and potential collaborations EMPLOYMENT HISTORY Scientific Investigator 2002 - 2009 Metabasis Therapeutics Project Leader, Liver-targeted thyroid hormone receptor agonist for the treatment of elevated LDL cholesterol Designed and implemented of sub-chronic safety studies, pharmacokinetic (PK) and pharmacodynamic (PD) studies in both small and large animals Performed complex statistical analyses of continuous, non-continuous and categorical data using JMP software (SAS Corporation), Sigma Plot, Basic pharmacokinetic analysis (WinNonLin-Pharsight, Inc.), and lipomic data analysis Designed and implemented a company-wide wellness program to encourage non-athletes to start and continue a voluntary wellness program. Program achieved more than 75% voluntary participation. Co-authored 5 published peer-reviewed manuscripts and 6 meeting presentations disclosing MB07811 for the treatment of elevated LDL cholesterol, obesity and hepatic steatosis Authored key portions of the pre-clinical Animal Pharmacology and Toxicology Studies section of the MB07811 IND

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Edward Cable

Resume

Postdoctoral Fellow through Assistant Professor 1994 –2002 Penn State College of Medicine Authored/co-authored 10 published peer-reviewed manuscripts and 3 funded grant applications as PI, co-authored several other grant applications Successfully secured and maintained external funding for academic position at >80% for the full duration of tenure Developed and implemented tissue culture methods for both primary cells and immortalized and transformed cell lines and engineered cell lines and microscopy methods including transmission electron microscopy and immuno-EM, scanning laser confocal and deconvolution microscopy Designed novel RNA gel shift , characterization of HBV antivirals in an ovel in vitro pharmacology HBV assay, used viral gene transfer vectors and methods in primary hepatocytes and cell lines Designed experiments and analyzed genomic data from cells and tissues Established collaborative academic efforts among PI’s from three different departments leading to the receipt of Program Project funding (5P01DK053430) >$1M/4 years: Harriet Isom, Michael Chorney, James Conner, and Mel Billingsley Graduate Student to Postdoctoral Research Associate University of Massachusetts Medical Center Authored/co-authored 17 peer reviewed publications Education and Professional Development University of Massachusetts Medical Center Emory University Grove City College

1990- 1994

Ph.D. Biochemistry Graduate Program Biochemistry B.S. Chemistry

Awards Metabasis, First in Human MB07811 Biology Project Leader American Liver Foundation Liver Scholar Award November, American Gastroenterology Association Student Research Award Runner-up Senior Research Award, Grove City College Publications 32 published peer-reviewed papers 36 abstracts 1 patent/patent application

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