Benign And Malignant Connective Tumors: Workshop 10

Benign and malignant connective tumors Workshop 10

Connective tumours • •

They are tumours with origin in multipotent mesenchymal cells that can differentiate and form differentiated connective tissues. Classification – By evolution: benign and malignant – By tissue origin: Benign Connective Tumors

Malignant Connective Tumors

+OMA

+SARCOMA

Lipoma

Liposarcoma

Chondroma

Chondrosarcoma

Fibroma

Fibrosarcoma

Osteoma

Osteosarcoma

Hemangioma, limfangioma

Angiosarcoma

Microscopy • • • • •

Chondroma Capillary hemangioma -skin Cavernous Hemangioma - liver Moderate differentiated fibrosarcoma Well differentiated osteosarcoma

Chondroma • •

Benign tumor are formed by hyaline cartilaginous tissue Microscopy  Nodular, well circumscribed and encapsulated tumor  Is composed by lobules of mature hyaline cartilage separated by connective vascular axes with role of support and nutrition  The tumoral cartilage is composed from basophilic chartliagenous matrix (chondrin) presenting chondroplasts that contains mature chondrocytes

Capillary hemangioma-skin • • •

• •

•

A benign tumor formed from numerous blood vessels. The tumor is located at the level of superficial and profound dermis. Is formed by tumoral lobules that contain numerous capillary vessels connected by connective tissue bands. The tumor has a lobular growth that confers the infiltrative character. The tumoral capillary vessels are lined by a normal endothelium. Some of them are unopened or collapsed, the others are opened containing blood.

Cavernous hemangioma liver • •

•

•

Is a benign tumour formed by numerous vascular spaces, located in the liver. The tumour is composed by tumoral lobuli that contain many large vascular spaces separated by connective tissue. The vascular spaces have different shapes and size, and are lined by a normal endothelium containing blood or thrombi. The tumour has lobular growth that confers the infiltrative character

Moderate differentiated fibrosarcoma • •

Is a connective malignant tumour resulting from proliferation of fibroblasts. Microscopy  The tumor has a hypercellular feature, is composed from fusiform atypical cells, disposed in bundles, but with a reduce production of collagen fibers.  The tumoral cells are resembling with fibroblasts, they have moderate pleomorphism and a greater number of mitoses than differentiated fibrosarcoma.  The tumoral stroma contains sarcomatous vessels.

Osteosarcoma • •

Is a malignant tumour that forms tumoral bone = osteogenic sarcoma In the structure of the tumour we can put in evidence:  Areas of fusiform non-differentiated cells of sarcomatous type.  Strands of osteoid tissue  The osseous lamellae containing atypical cells  The tumor contains sarcomatous vessels, necrosis and hemorrhage

Osteosarcoma